eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
4/2005
vol. 4
 
Share:
Send email
Share:
abstract:

The case of using antiangiogenic agent – plasmide vector psFLT and radiochemotherapy in locally advanced vulvar cancer

Grzegorz Panek
,
Krzysztof Gawrychowski
,
Mariusz Bidziński
,
Ryszard Krynicki
,
Maciej Małecki

Prz Menopauz 2005; 4: 17–21
Online publish date: 2005/08/31
View full text Get citation
 
This is a case report documenting a successful use of antiangiogenic agent- plasmide vector psFLT with successive chemo-radiotherapy and radical surgery in patient with primarily unoperable invasive carcinoma of the vulva.
After 3 courses of subcutaneous injection of 30 micrograms of Plasmide vector psFLTa significant reduction of the tumor size was obtained.
Subsequently chemo-irradiation was 5-Fluorouracil and Mitomycin-C was carried out resulting in complete clinical regression of the tumor. Radical vulvectomy and inguino-femoral limphadenectomy was performed 6 weeks after completion of chemo-irradiation. Microscopic examination of the specimen revealed a complete eradication of the malignant tissue.
The case demonstrates a significant potential of antiangiogenic therapy combiened with chemo-irradiation for locally advanced carcinoma of the vulva. This experimental method of treatment deserves further investigation.
keywords:

vulvar cancer, angiogenesis inhibitors, chemo-irradiation
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.