The combination of tramadol with dexketoprofen in clinical practice – the progress in the treatment of pain

Jarosław Woroń; Jerzy Wordliczek

eISSN: 2450-4459
ISSN: 2450-3517

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vol. 3

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abstract:

Review paper

The combination of tramadol with dexketoprofen in clinical practice – the progress in the treatment of pain

Jarosław Woroń

,

Jerzy Wordliczek

Online publish date: 2017/03/09

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The co-administration of two or more analgesics with different mechanisms of action and co-analgesics (antidepressants, anticonvulsants, steroids, antispasmodics, NMDA receptor antagonists) is widely used in the relief of acute pain (particularly postoperative) and in the treatment of chronic pain.

There are many potential benefits of combination in pharmacotherapy of pain and the possibility to achieve a synergistic or additive effect, which in turn permits the use of lower doses of the individual drugs, and can potentially reduce the incidence of side effects. In the case of combination of tramadol and dexketoprofen, there is a synergism, which is used in the treatment of inflammatory pain. The paper discusses the indications for use of this innovative combination registered for the treatment of acute pain.

keywords:

The combination of tramadol with dexketoprofen in clinical practice – the progress in the treatment of pain

Jarosław Woroń , Jerzy Wordliczek

pain, pharmacotherapy, combination drugs

Jarosław Woroń

,

Jerzy Wordliczek