The correlation of expression of VEGF and EGFR with SUV of <sup>18</sup>FDG-PET-CT in non-small cell lung cancer

Xiguang Liu; Hongjun Zhang; Xiaoyun Yu; Tingting Song; Peng Huang; Haichao Wang; Shan-ai Song

doi:10.5114/wo.2014.45308

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2014
vol. 18

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abstract:

Original paper

The correlation of expression of VEGF and EGFR with SUV of ¹⁸FDG-PET-CT in non-small cell lung cancer

Xiguang Liu

,

Hongjun Zhang

,

Xiaoyun Yu

,

Tingting Song

,

Peng Huang

,

Haichao Wang

,

Shan-ai Song

Contemp Oncol (Pozn) 2014; 18 (5): 334–339

DOI: https://doi.org/10.5114/wo.2014.45308

Online publish date: 2014/11/05

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Aim of the study: To explore the correlation of the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) with maximum standardised uptake value (SUV_max) of ¹⁸FDG-PET-CT in non-small cell lung cancer (NSCLC).

Material and methods: Thirty patients received PET-CT imaging protocol first, and then all the patients underwent needle biopsy though CT guidance. The tumour tissue of each patient was taken from two biopsy areas: one area was SUV_max = 2.5–5, and the other was SUV_max > 5. Expression of VEGF and EGFR were detected and analysed by immunohistochemical staining.

Results: The expressions of both VEGF and EGFR had no statistically significant correlation with SUV_max in age, gender, pathology, or differentiation (p > 0.05). The expressions of both VEGF and EGFR had statistically significant correllation with SUV_max in tumour size and clinical stage (p < 0.05). SUV_max correlated positively with VEGF and EGFR expressions (r = 0.879, p < 0.05).

Conclusions: SUV_max correlated positively with expressions of VEGF and EGFR (r = 0.879, p = 0.000; r = 0.839, and p = 0.000, respectively). This study may provide guidance for radiotherapy of NSCLC.

keywords:

The correlation of expression of VEGF and EGFR with SUV of 18FDG-PET-CT in non-small cell lung cancer

Xiguang Liu , Hongjun Zhang , Xiaoyun Yu , Tingting Song , Peng Huang , Haichao Wang , Shan-ai Song

vascular endothelial growth factor, non-small cell lung cancer

The correlation of expression of VEGF and EGFR with SUV of ¹⁸FDG-PET-CT in non-small cell lung cancer

Xiguang Liu

,

Hongjun Zhang

,

Xiaoyun Yu

,

Tingting Song

,

Peng Huang

,

Haichao Wang

,

Shan-ai Song