eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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5/2014
vol. 18
 
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abstract:
Original paper

The correlation of expression of VEGF and EGFR with SUV of 18FDG-PET-CT in non-small cell lung cancer

Xiguang Liu
,
Hongjun Zhang
,
Xiaoyun Yu
,
Tingting Song
,
Peng Huang
,
Haichao Wang
,
Shan-ai Song

Contemp Oncol (Pozn) 2014; 18 (5): 334–339
Online publish date: 2014/11/05
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Aim of the study: To explore the correlation of the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) with maximum standardised uptake value (SUVmax) of 18FDG-PET-CT in non-small cell lung cancer (NSCLC).

Material and methods: Thirty patients received PET-CT imaging protocol first, and then all the patients underwent needle biopsy though CT guidance. The tumour tissue of each patient was taken from two biopsy areas: one area was SUVmax = 2.5–5, and the other was SUVmax > 5. Expression of VEGF and EGFR were detected and analysed by immunohistochemical staining.

Results: The expressions of both VEGF and EGFR had no statistically significant correlation with SUVmax in age, gender, pathology, or differentiation (p > 0.05). The expressions of both VEGF and EGFR had statistically significant correllation with SUVmax in tumour size and clinical stage (p < 0.05). SUVmax correlated positively with VEGF and EGFR expressions (r = 0.879, p < 0.05).

Conclusions: SUVmax correlated positively with expressions of VEGF and EGFR (r = 0.879, p = 0.000; r = 0.839, and p = 0.000, respectively). This study may provide guidance for radiotherapy of NSCLC.
keywords:

vascular endothelial growth factor, non-small cell lung cancer

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