The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning

Paulina Cegła; Ewa Burchardt; Ewa Wierzchosławska; Andrzej Roszak; Witold Cholewiński

doi:10.5114/wo.2019.89248

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2019
vol. 23

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abstract:

Original paper

The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning

Paulina Cegła

¹

,

Ewa Burchardt

^{2, 3}

,

Ewa Wierzchosławska

^{2, 4}

,

Andrzej Roszak

^{2, 3}

,

Witold Cholewiński

^{1, 2}

Department of Nuclear Medicine, Greater Poland Cancer Centre, Poznan, Poland
Chair and Department of Electroradiology, Poznan University of Medical Sciences, Poland
Department of Radiotherapy and Oncological Gynaecology, Greater Poland Cancer Centre, Poznan, Poland
Department of Radiology, Greater Poland Cancer Centre, Poznan, Poland

Contemp Oncol (Pozn) 2019; 23 (3): 183-186

DOI: https://doi.org/10.5114/wo.2019.89248

Online publish date: 2019/10/31

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AMA

Cegła P, Burchardt E, Wierzchosławska E, Roszak A, Cholewiński W. The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning. Contemporary Oncology/Współczesna Onkologia. 2019;23(3):183-186. doi:10.5114/wo.2019.89248.

APA

Cegła, P., Burchardt, E., Wierzchosławska, E., Roszak, A.,  & Cholewiński, W. (2019). The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning. Contemporary Oncology/Współczesna Onkologia, 23(3), 183-186. https://doi.org/10.5114/wo.2019.89248

Chicago

Cegła, Paulina, Ewa Burchardt, Ewa Wierzchosławska, Andrzej Roszak,  and Witold Cholewiński. 2019. "The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning". Contemporary Oncology/Współczesna Onkologia 23 (3): 183-186. doi:10.5114/wo.2019.89248.

Harvard

Cegła, P., Burchardt, E., Wierzchosławska, E., Roszak, A.,  and Cholewiński, W. (2019). The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning. Contemporary Oncology/Współczesna Onkologia, 23(3), pp.183-186. https://doi.org/10.5114/wo.2019.89248

MLA

Cegła, Paulina et al. "The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning." Contemporary Oncology/Współczesna Onkologia, vol. 23, no. 3, 2019, pp. 183-186. doi:10.5114/wo.2019.89248.

Vancouver

Cegła P, Burchardt E, Wierzchosławska E, Roszak A, Cholewiński W. The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning. Contemporary Oncology/Współczesna Onkologia. 2019;23(3):183-186. doi:10.5114/wo.2019.89248.

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Introduction
Gynaecological cancers, including cervical cancer, often require a multidisciplinary approach that includes external beam radiotherapy, chemotherapy, and/or surgical treatment. Biological parameters of the tumour evaluated in ¹⁸F-FDG-PET/CT are used for target volume delineation in radiotherapy planning. The choice of segmentation method may affect the assessment of metabolic tumour volume (MTV) in ¹⁸F-FDG-PET/CT.

Aim of the study
To find the optimal segmentation method for the assessment of primary MTV in ¹⁸F-FDG-PET/CT in cervical cancer patients for radiotherapy planning.

Material and methods
Retrospective analysis was performed on a group of 30 patients with newly diagnosed, histologically confirmed cervical cancer. The primary MTVs were assessed by SUV_max and SUV_mean values; three segmentation methods were used to assess the primary MTV: constant threshold of SUV_max of 2.5, threshold of SUV_max 35%, and threshold of SUV_max 45%. The MTVs were compared with the tumour volumes obtained in magnetic resonance imaging (MRI), which was the “gold standard”, to select the best optimal segmentation method reflecting the tumour size. Wilcoxon-Mann-Whitney and t-test were used for statistical analysis.

Results
Depending on the segmentation method chosen, significant differences in the MTVs were obtained (p < 0.001). The highest volumes were obtained using the method based on constant SUV_max of 2.5, while the smallest in case of threshold of SUV_max of 45%. Regarding the volume determined by MRI, a 35% SUV_max threshold was chosen as the most reliable method.

Conclusions
The choice of appropriate segmentation method has a significant impact on the primary MTV assessment in ¹⁸F-FDG-PET/CT in patients with cervical cancer.

keywords:

The effect of different segmentation methods on primary tumour metabolic volume assessed in 18F-FDG-PET/CT in patients with cervical cancer, for radiotherapy planning

Paulina Cegła 1 , Ewa Burchardt 2, 3 , Ewa Wierzchosławska 2, 4 , Andrzej Roszak 2, 3 , Witold Cholewiński 1, 2

cervical cancer, segmentation, 18F-fluorodeoxyglucose, PET/CT, SUV

Paulina Cegła

¹

,

Ewa Burchardt

^{2, 3}

,

Ewa Wierzchosławska

^{2, 4}

,

Andrzej Roszak

^{2, 3}

,

Witold Cholewiński

^{1, 2}

cervical cancer, segmentation, ¹⁸F-fluorodeoxyglucose, PET/CT, SUV