The effect of feeding mice during gestation and nursing with <i>Rhodiola kirilowii</i> extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny

Lewicki S, Orłowski P, Krzyżowska M, Kiepura A, Skopińska-Różewska E, Zdanowski R. The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny. Central European Journal of Immunology. 2017;42(1):10-16. doi:10.5114/ceji.2017.67313.

APA

Lewicki, S., Orłowski, P., Krzyżowska, M., Kiepura, A., Skopińska-Różewska, E.,  & Zdanowski, R. (2017). The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny. Central European Journal of Immunology, 42(1), 10-16. https://doi.org/10.5114/ceji.2017.67313

Chicago

Lewicki, Sławomir, Piotr Orłowski, Małgorzata Krzyżowska, Anna Kiepura, Ewa Skopińska-Różewska,  and Robert Zdanowski. 2017. "The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny". Central European Journal of Immunology 42 (1): 10-16. doi:10.5114/ceji.2017.67313.

Harvard

Lewicki, S., Orłowski, P., Krzyżowska, M., Kiepura, A., Skopińska-Różewska, E.,  and Zdanowski, R. (2017). The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny. Central European Journal of Immunology, 42(1), pp.10-16. https://doi.org/10.5114/ceji.2017.67313

MLA

Lewicki, Sławomir et al. "The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny." Central European Journal of Immunology, vol. 42, no. 1, 2017, pp. 10-16. doi:10.5114/ceji.2017.67313.

Vancouver

Lewicki S, Orłowski P, Krzyżowska M, Kiepura A, Skopińska-Różewska E, Zdanowski R. The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny. Central European Journal of Immunology. 2017;42(1):10-16. doi:10.5114/ceji.2017.67313.

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Rhodiola kirilowii, a member of Crassulaceae family, grows wildly in Asiatic mountains and is also cultivated in some European countries. Its underground parts traditionally are used for enhance physical and mental performance of the body.

In our previous papers we reported immuno- and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in mice. In the present work we evaluated the effect of Rhodiola kirilowii water- (RKW) or hydro- alcoholic (RKW-A) extracts and epigallocatechin (one of the polyphenols present in these extracts) given to mice, during pregnancy and nursing period, on the number and localization of CD4+ and CD8+ cells in spleens of adult progeny mice. Previously, we observed several abnormalities in functionality of spleen cells collected from these mice. No differences in CD4+ T cells localisation or numbers were found between all tested mice groups. In contrast, CD8+ T cells localisation and staining were altered in progeny of water or alcohol extract-fed mice. CD8+ T cells were found not only in the PALS but also in the B cell follicle and in the red pulp. Furthermore, CD8+ T cells from T cell zones in the progeny of extract-fed mice showed much intensive staining for CD8 antigen and significantly higher numbers per area in comparison to control mice.

keywords:

The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny

Sławomir Lewicki , Piotr Orłowski , Małgorzata Krzyżowska , Anna Kiepura , Ewa Skopińska-Różewska , Robert Zdanowski

Rhodiola kirilowii, epigallocatechin, spleen, progeny, mice

**The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny**

Sławomir Lewicki

,

Piotr Orłowski

,

Małgorzata Krzyżowska

,

Anna Kiepura

,

Ewa Skopińska-Różewska

,

Robert Zdanowski