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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2019
vol. 36
 
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abstract:
Original paper

The effect of fennel essential oil and trans-anethole on antibacterial activity of mupirocin against Staphylococcus aureus isolated from asymptomatic carriers

Paweł Kwiatkowski
1
,
Agata Pruss
1
,
Helena Masiuk
1
,
Magdalena Mnichowska-Polanowska
1
,
Maciej Kaczmarek
2
,
Stefania Giedrys-Kalemba
1
,
Barbara Dołęgowska
1
,
Hanna Zielińska-Bliźniewska
3
,
Jurek Olszewski
4
,
Monika Sienkiewicz
3

  1. Department of Microbiology, Immunology and Laboratory Medicine, Pomeranian Medical University, Szczecin, Poland
  2. Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland
  3. Department of Allergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Lodz, Poland
  4. Department of Otolaryngology and Laryngological Oncology, 2nd Chair of Otolaryngology, Medical University of Lodz, Lodz, Poland
Adv Dermatol Allergol 2019; XXXVI (3): 308-314
DOI: https://doi.org/10.5114/ada.2018.76425
Online publish date: 2019/06/18
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Introduction
Staphylococcus aureus constitutes the most pathogenic species within the staphylococcal genus. Humans remain the major reservoirs of this pathogen which colonizes mostly anterior nares of healthy individuals.

Aim
To investigate the effect of fennel essential oil (FEO) and trans-anethole (tA) on antibacterial activity of mupirocin (MUP) against S. aureus strains isolated from asymptomatic carriers.

Material and methods
The content of the FEO was analysed with use of the GC-MS method. The research done on 43 S. aureus isolates with different resistance patterns, obtained from nasal vestibule. Antibacterial activity of MUP in combination with FEO or tA was examined using the agar dilution method and E-test method. The data analysis was done with the Pearson’s c2 test.

Results
The chemical composition of FEO was consistent with the European Pharmacopoeia (EP) for the main constituent – tA (77.9%) according to the EP recommendations. Macrolide-lincosamide-streptogramin B resistance phenotype was prevalent among 39.5% of S. aureus isolates. FEO concentrations of 2.0% and 2.5% revealed antibacterial activity against 76.7% of isolates, whereas tA inhibited S. aureus growth at concentrations > 4.0%. The MIC values for MUP combined with FEO as well as for MUP combined with tA were < 0.064 µg/ml for 79.1% and 86.0% of S. aureus isolates, respectively.

Conclusions
Our experiment revealed FEO and tA influence on MUP effectiveness. The combination of MUP with FEO as well as MUP with tA are worth considering to implement in S. aureus eradication procedures. These findings will be useful in designing efficient antistaphylococcal agents which can limit the emergence of antibiotic resistance.

keywords:

Staphylococcus aureus, mupirocin, fennel essential oil, trans-anethole
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