eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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4/2021
vol. 20
 
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abstract:
Original paper

The effect of low-dose combined hormone therapy (oestradiol and norethindrone acetate) on serum C-reactive protein levels and life quality in natural menopause women

Servin Gocer
1
,
Suleyman Guven
2
,
Hidayet Sal
2
,
Emine Seda Guvendag Guven
2

  1. Department of Obstetrics and Gynaecology, Okan University School of Medicine, Istanbul, Turkey
  2. Department of Obstetrics and Gynaecology, Karadeniz Technical University School of Medicine, Trabzon, Turkey
Menopause Rev 2021; 20(4): 177-183
DOI: https://doi.org/10.5114/pm.2021.110935
Online publish date: 2021/11/24
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Introduction
To assess the effect of low-dose combined oestradiol and norethindrone acetate hormone therapy (HT) on serum C-reactive protein (CRP) levels and life quality in natural menopause women.

Material and methods
Forty-five natural menopause women admitted to the clinic during a 1-year period and diagnosed as menopause, who planned to have HT for menopausal symptoms, were enrolled in this prospective study. The serum CRP levels were measured, and vasomotor symptoms scores were graded according to the Blatt-Kupperman menopause index, and life quality scores according to the Menopause-Specific Quality of Life Questionnaire (MENQOL) were recorded before and after (3 months later) hormone therapy.

Results
The Blatt-Kupperman menopause index and MENQOL scores were significantly decreased after 3 months of low-dose treatment. No significant difference was found between white blood cell counts and serum CRP levels before and after 3 months of hormone therapy.

Conclusions
Considering all HT types and biochemical effects, low-dose HT, which had positive results in terms of quality of life, was a safe treatment and could be preferred to conventional-dose preparations in cases without contraindications. Low-dose combined HT containing oestradiol and norethindrone acetate did not alter the serum CRP level in postmenopausal cases.

keywords:

Blatt-Kupperman index, CRP, oestradiol, Menopause-Specific Quality of Life Questionnaire (MENQOL), norethindrone acetate
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