Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
Current Issue Manuscripts accepted About the journal Editorial board Abstracting and indexing Archive Ethical standards and procedures Contact Instructions for authors Journal's Reviewers Special Information
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2024
vol. 41
 
Share:
Send email
Share:
abstract:
Original paper

The effect of normobaric hypoxia on acute exercise-induced changes in blood sphingoid base-1-phosphates metabolism in cyclists

Katarzyna Hodun
1
,
Miłosz Czuba
2
,
Kamila Płoszczyca
3
,
Jerzy Sadowski
4
,
Józef Langfort
5
,
Adrian Chabowski
1
,
Marcin Baranowski
1

  1. Department of Physiology, Medical University of Białystok, Białystok, Poland
  2. Faculty of Rehabilitation, Józef Piłsudski University of Physical Education in Warsaw, Warsaw, Poland
  3. Department of Kinesiology, Institute of Sport – National Research Institute, Warsaw, Poland
  4. Faculty of Physical Education and Health, Józef Piłsudski University of Physical Education in Warsaw, Warsaw, Poland
  5. Department of Sports Theory, Jerzy Kukuczka Academy of Physical Education, Katowice, Poland
Biol Sport. 2024;41(2):37–45
DOI: https://doi.org/10.5114/biolsport.2024.131414
Online publish date: 2023/09/21
View full text Get citation
 
PlumX metrics:
Extracellularsphingosine-1-phosphate (S1P) emerged as an important regulator of muscle function. We previously found that plasma S1P concentration is elevated in response to acute exercise and training. Interestingly, hypoxia, which is commonly utilized in training programs, induces a similar effect. Therefore, the aim of the current study was to determine the effect of normobaric hypoxia on exercise-induced changes in blood sphingolipid metabolism. Fifteen male competitive cyclists performed a graded cycling exercise until exhaustion (GE) and a simulated 30 km individual time trial (TT) in either normoxic or hypoxic (FiO2 = 16.5%) conditions. Blood samples were taken before the exercise, following its cessation, and after 30 min of recovery. We found that TT increased dihydrosphingosine-1-phosphate (dhS1P) concentration in plasma (both HDL- and albuminbound) and blood cells, as well as the rate of dhS1P release from erythrocytes, regardless of oxygen availability. Plasma concentration of S1P was, however, reduced during the recovery phase, and this trend was augmented by hypoxia. On the other hand, GE in normoxia induced a selective increase in HDL-bound S1P. This effect disappeared when the exercise was performed in hypoxia, and it was associated with reduced S1P level in platelets and erythrocytes. We conclude that submaximal exercise elevates total plasma dhS1P concentration via increased availability of dihydrosphingosine resulting in enhanced dhS1P synthesis and release by blood cells. Maximal exercise, on the other hand, induces a selective increase in HDL-bound S1P, which is a consequence of mechanisms not related to blood cells. We also conclude that hypoxia reduces post-exercise plasma S1P concentration.
keywords:

ceramide, red blood cells, simulated altitude, sphinganine-1-phosphate, sphingomyelin, thrombocytes

  
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.