eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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1/2014
vol. 13
 
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abstract:
Original paper

The effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up

Sławomir Woźniak
,
Piotr Szkodziak
,
Piotr Czuczwar
,
Ewa Woźniakowska
,
Maciej Paszkowski
,
Paweł Milart
,
Tomasz Paszkowski

Prz Menopauzalny 2014; 13(1): 18-21
DOI: https://doi.org/10.5114/pm.2014.41091
Online publish date: 2014/03/10
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Aim of the study: The purpose of the study was to monitor the effect of ulipristal acetate treatment on symptomatic uterine fibroids within 12-months follow-up.

Material and methods: Fifty six patients with symptomatic uterine fibroids qualified for surgical treatment were included in the prospective observational study. All patients received preoperative oral UPA treatment for 3 months (1 × 5 mg). Patients that refused surgical treatment after UPA therapy were followed-up for the next 9 months. The volume of the intramural fibroid was estimated by TV-US using and integrated VOCAL 3D imaging program at baseline, after 3 months of UPA treatment and further at 3-months intervals.

Results: Before UPA mean dominant fibroid volume was estimated to be 216.0 cm3 (38.4-768.2 cm3) and decreased to 117.6 cm3 (12.6-668.0 cm3) after 3 months of UPA therapy. Mean percentage volume reduction was 45.6%. Mean hemoglobin level increased from an initial 10.1 g/dL (6.8-12.9 g/dL) to 12.6 g/dL (10.1-14.8) after 3 months of UPA therapy. At 12 months after initiating UPA treatment mean dominant fibroid volume decreased by 43.9%. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months.

Conclusions: Three month UPA therapy decreases fibroid volume and improves hemoglobin level before planned surgical treatment. In one third of followed-up patients the effect of 3 month UPA therapy persisted for the next 9 months.
keywords:

ulipristal acetate, uterine fibroids, ultrasound
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