The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies

Haoyue Deng; Yongpeng He; Xiaoqin Fu; Zhiqiang Mei; Yi Li

doi:10.5114/ada.2022.119074

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

The efficacy of high-flow oxygen versus conventional oxygen for asthma control: a meta-analysis of randomized controlled studies

Haoyue Deng

^{1, 2}

,

Yongpeng He

³

,

Xiaoqin Fu

³

,

Zhiqiang Mei

²

,

Yi Li

⁴

Department of Gastroenterology Suining First People's Hospital, Suining, Sichuan, China
The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China
Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, China
Department of Thoracic Surgery Suining Central Hospital, Suining, Sichuan, China

Adv Dermatol Allergol 2022; XXXIX (6): 1077-1082

DOI: https://doi.org/10.5114/ada.2022.119074

Online publish date: 2022/09/07

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AMA

Deng H, He Y, Fu X, Mei Z, Li Y. The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(6):1077-1082. doi:10.5114/ada.2022.119074.

APA

Deng, H., He, Y., Fu, X., Mei, Z.,  & Li, Y. (2022). The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(6), 1077-1082. https://doi.org/10.5114/ada.2022.119074

Chicago

Deng, Haoyue, Yongpeng He, Xiaoqin Fu, Zhiqiang Mei,  and Yi Li. 2022. "The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 39 (6): 1077-1082. doi:10.5114/ada.2022.119074.

Harvard

Deng, H., He, Y., Fu, X., Mei, Z.,  and Li, Y. (2022). The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 39(6), pp.1077-1082. https://doi.org/10.5114/ada.2022.119074

MLA

Deng, Haoyue et al. "The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 39, no. 6, 2022, pp. 1077-1082. doi:10.5114/ada.2022.119074.

Vancouver

Deng H, He Y, Fu X, Mei Z, Li Y. The efficacy of high-flow oxygen versus conventional
oxygen for asthma control: a meta-analysis
of randomized controlled studies. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2022;39(6):1077-1082. doi:10.5114/ada.2022.119074.

Introduction
The efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control remains controversial.

Aim
This meta-analysis aims to explore the influence of high-flow oxygen versus conventional oxygen therapy on asthma control.

Material and methods
We have searched PubMed, Embase, Web of Science, EBSCO, and Cochrane library databases, and included randomized controlled trials (RCTs) assessing the efficacy of high-flow oxygen versus conventional oxygen therapy for asthma control.

Results
Four RCTs are included in this meta-analysis. Overall, compared with conventional oxygen therapy for asthma, high-flow oxygen is associated with a significantly lower dyspnoea score (standard mean difference (SMD) = –0.63; 95% confidence interval (CI): –1.08 to –0.17; p = 0.008), but reveals no remarkable influence on PaCO2 (SMD = 0.28; 95% CI: –0.22 to 0.77; p = 0.28), PaO2 (SMD = 0.44; 95% CI: –1.34 to 2.22; p = 0.63), intubation rate (OR = 1.09; 95% CI: 0.15 to 8.21; p = 0.93) or hospital length of stay (SMD = –0.07; 95% CI: –0.41 to 0.27; p = 0.67).

Conclusions
High-flow oxygen may benefit to reduce/may be more beneficial in reducing the dyspnoea score than conventional oxygen therapy for asthma, but shows no improvement in PaCO2, PaO2, intubation or hospital length of stay.

keywords:

The efficacy of high-flow oxygen versus conventional oxygen for asthma control: a meta-analysis of randomized controlled studies

Haoyue Deng 1, 2 , Yongpeng He 3 , Xiaoqin Fu 3 , Zhiqiang Mei 2 , Yi Li 4

high-flow oxygen, conventional oxygen, asthma, randomized controlled trials

Haoyue Deng

^{1, 2}

,

Yongpeng He

³

,

Xiaoqin Fu

³

,

Zhiqiang Mei

²

,

Yi Li

⁴