The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer

Theresa L. Whiteside

doi:10.5114/wo.2018.73882

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Contemporary Oncology

1/2018

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abstract:

Review paper

The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer

Theresa L. Whiteside

Contemp Oncol (Pozn) 2018; 22 (1A): 38–40

DOI: https://doi.org/10.5114/wo.2018.73882

Online publish date: 2018/03/08

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Exosomes, small (30-150nm) extracellular vesicles of endocytic origin, are present in all body fluids of cancer patients. Tumor-derived exosomes, TEX, emerge as potentially promising non-invasive biomarkers of tumor progression and of immune cell dysfunction in cancer. Exosomes isolated from plasma by size exclusion chromatography can be fractionated into TEX and non-TEX by immune capture on beads. Profiling of molecular and genetic contents of TEX shows that levels if immunosuppressive proteins, such as PD-L1, carried by TEX associate with disease progression. The data suggest that TEX have a to serve as tumor surrogates, while immune cell-derived exosomes might serve as biomarkers of immune dysfunction in cancer.

keywords:

The emerging role of plasma exosomes in diagnosis, prognosis and therapies of patients with cancer

Theresa L. Whiteside

exosomes, tumor-derived exosomes (TEX), cancer prognosis, cancer immunotherapy