The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy

Dominika Leś; Maria Saduś-Wojciechowska; Tomasz Rutkowski; Andrzej Wygoda; Krzysztof Składowski

doi:10.5114/wo.2019.89247

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2019
vol. 23

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abstract:

Original paper

The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy

Dominika Leś

¹

,

Maria Saduś-Wojciechowska

²

,

Tomasz Rutkowski

¹

,

Andrzej Wygoda

¹

,

Krzysztof Składowski

¹

I Department of Radiotherapy and Chemotherapy, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Gliwice, Poland
Department of Bone Marrow Transplantation and Haematology-Oncology, Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Contemp Oncol (Pozn) 2019; 23 (3): 178-182

DOI: https://doi.org/10.5114/wo.2019.89247

Online publish date: 2019/10/31

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AMA

Leś D, Saduś-Wojciechowska M, Rutkowski T, Wygoda A, Składowski K. The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy. Contemporary Oncology/Współczesna Onkologia. 2019;23(3):178-182. doi:10.5114/wo.2019.89247.

APA

Leś, D., Saduś-Wojciechowska, M., Rutkowski, T., Wygoda, A.,  & Składowski, K. (2019). The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy. Contemporary Oncology/Współczesna Onkologia, 23(3), 178-182. https://doi.org/10.5114/wo.2019.89247

Chicago

Leś, Dominika, Maria Saduś-Wojciechowska, Tomasz Rutkowski, Andrzej Wygoda,  and Krzysztof Składowski. 2019. "The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy". Contemporary Oncology/Współczesna Onkologia 23 (3): 178-182. doi:10.5114/wo.2019.89247.

Harvard

Leś, D., Saduś-Wojciechowska, M., Rutkowski, T., Wygoda, A.,  and Składowski, K. (2019). The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy. Contemporary Oncology/Współczesna Onkologia, 23(3), pp.178-182. https://doi.org/10.5114/wo.2019.89247

MLA

Leś, Dominika et al. "The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy." Contemporary Oncology/Współczesna Onkologia, vol. 23, no. 3, 2019, pp. 178-182. doi:10.5114/wo.2019.89247.

Vancouver

Leś D, Saduś-Wojciechowska M, Rutkowski T, Wygoda A, Składowski K. The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy. Contemporary Oncology/Współczesna Onkologia. 2019;23(3):178-182. doi:10.5114/wo.2019.89247.

PlumX metrics:

Between January 2017 and July 2018 103 patients were included in a prospective study of erythropoietin (EPO) monitoring. The group consisted of 33% patients with oropharynx, 29% with oral cavity, 13% with nasopharynx, 6% with larynx, 6% with hypopharynx, 8% with unknown primary cancer, 4% with nasal cavity, and 1% with salivary gland cancer. Clinic stage: T4 – 50, T3 – 21, T2 – 14, T1 – 10, T0 – 8, and N3 – 19, N2 – 61, N1 – 10, N0 – 13. All patients received from one to four cycles of induction chemotherapy. EPO was measured in blood serum by enzyme-labelled chemiluminescent immunometric assay, using an Immulite 2000XPi analyser before the administration and on day 11 of each chemotherapy cycle.

During induction chemotherapy the EPO level was elevated in all patients, which is expressed by means of medians: 10.7 (p = 0.000001) in the middle of cycle 1; 10.9 (p = 0.66) before cycle 2; 14.35 (p = 0.000177) in the middle of cycle 2; 14.95 (p = 0.39) before cycle 3, 17.00 (p = 0.00078) in the middle of cycle 3, and 20.9 after cycle 3 (p = 0.41).

The correlation analysis conducted indicates that the administration of one chemotherapy dose results in higher EPO release (two-fold increase in EPO concentration) which intensifies reticulocytes (REC) production but without haemoglobin concentration in reticulocytes (HGB-REC) growth. In consequence, it leads to a decrease in RBC and HGB concentration (29–32 cases). The administration of two and three chemotherapy doses results in the subsequent higher release of EPO, which does not intensify REC production. In consequence, anaemia increases (35 cases).

keywords:

The endogenous erythropoietin in correlation with other erythrocytic parameters in patients with head and neck squamous cell carcinoma treated with platinum-based induction chemotherapy

Dominika Leś 1 , Maria Saduś-Wojciechowska 2 , Tomasz Rutkowski 1 , Andrzej Wygoda 1 , Krzysztof Składowski 1

erythropoietin, cisplatin, carboplatin, erythropoietin receptor

Dominika Leś

¹

,

Maria Saduś-Wojciechowska

²

,

Tomasz Rutkowski

¹

,

Andrzej Wygoda

¹

,

Krzysztof Składowski

¹