The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis

Małgorzata Mrugacz; Janusz Żak; Alina Bakunowicz-Łazarczyk; Jolanta Wysocka; Alina Minarowska; Karol Radomski

eISSN: 2719-3209
ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica

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2/2006
vol. 108

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abstract:

Original paper

The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis

Małgorzata Mrugacz

¹

,

Janusz Żak

²

,

Alina Bakunowicz-Łazarczyk

¹

,

Jolanta Wysocka

²

,

Alina Minarowska

³

,

Karol Radomski

²

Z Kliniki Okulistyki Dziecięcej Akademii Medycznej w Białymstoku
Z Zakładu Pediatrycznej Diagnostyki Laboratoryjnej Akademii Medycznej w Białymstoku
Z III Kliniki Chorób Dzieci Akademii Medycznej w Białymstoku

Online publish date: 2006/06/25

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AMA

Mrugacz M, Żak J, Bakunowicz-Łazarczyk A, Wysocka J, Minarowska A, Radomski K. The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica. 2006;108(2):178-179.

APA

Mrugacz, M., Żak, J., Bakunowicz-Łazarczyk, A., Wysocka, J., Minarowska, A.,  & Radomski, K. (2006). The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica, 108(2), 178-179.

Chicago

Mrugacz, Małgorzata, Janusz Żak, Alina Bakunowicz-Łazarczyk, Jolanta Wysocka, Alina Minarowska,  and Karol Radomski. 2006. "The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis". Klinika Oczna / Acta Ophthalmologica Polonica 108 (2): 178-179.

Harvard

Mrugacz, M., Żak, J., Bakunowicz-Łazarczyk, A., Wysocka, J., Minarowska, A.,  and Radomski, K. (2006). The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica, 108(2), pp.178-179.

MLA

Mrugacz, Małgorzata et al. "The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis." Klinika Oczna / Acta Ophthalmologica Polonica, vol. 108, no. 2, 2006, pp. 178-179.

Vancouver

Mrugacz M, Żak J, Bakunowicz-Łazarczyk A, Wysocka J, Minarowska A, Radomski K. The evaluation of the expression 
of intercellulare adhesion molecule 
(ICAM-1) by conjunctival epithelial 
cells of patients with cystic fibrosis. Klinika Oczna / Acta Ophthalmologica Polonica. 2006;108(2):178-179.

Purpose
To investigate the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis

Material and methods
15 patients with cystic fibrosis and 15 control subjects were included in this study. Impression cytology specimens were collected and analyzed by flow cytometry and analyzed by flow cytometry.

Results
A significant increase of ICAM-1 expression by epithelial cells was found in patients with cystic fibrosis compared with normal eyes.

Conclusions
Increase of ICAM-1 expression by epithelial cells in cystic fibrosis patients suggests, that the inflammation appears to have a role in the pathogenesis of the ocular surface changes and may be a marker of the inflammatory status in cystic fibrosis.

keywords:

The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis

Małgorzata Mrugacz 1 , Janusz Żak 2 , Alina Bakunowicz-Łazarczyk 1 , Jolanta Wysocka 2 , Alina Minarowska 3 , Karol Radomski 2

ICAM-1, cystic fibrosis, impression cytology, flow cytometry

Małgorzata Mrugacz

¹

,

Janusz Żak

²

,

Alina Bakunowicz-Łazarczyk

¹

,

Jolanta Wysocka

²

,

Alina Minarowska

³

,

Karol Radomski

²