eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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4/2023
vol. 22
 
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abstract:
Review paper

The expression and possible role of corticotropin-releasing hormone family peptides and their corresponding receptors in gynaecological malignancies and premalignant conditions: a systematic review

Angelos Dimas
1
,
Chrysoula Margioula-Siarkou
1
,
Anastasia Politi
2
,
Alexandros Sotiriadis
1
,
Alexios Papanikolaou
2
,
Konstantinos Dinas
1
,
Stamatios Petousis
1

  1. 2nd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece
  2. 1st Dermatology Department, “Andreas Syggros” Hospital for Skin Diseases, National and Kapodistrian University of Athens, Athens, Greece
Menopause Rev 2023; 22(4): 227-235
DOI: https://doi.org/10.5114/pm.2023.133878
Online publish date: 2023/12/21
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The aim of this systematic review is to investigate the impact of corticotropin-releasing hormone (CRH) family peptides and their corresponding receptors on human physiology and disease onset, with a specific focus on gynaecological malignancies such as breast, endometrial, ovarian, vulvar, and cervical cancer. A comprehensive systematic review of 3 medical databases was conducted by 2 independent reviewers. We reviewed studies that explored the expression and role of CRH peptides in various aspects of cancer biology, in the context of breast, endometrial, ovarian, vulvar, and cervical cancer. Our findings reveal that CRH family peptides and their receptors, CRHR1 and CRHR2, are expressed in diverse gynaecological tissues, including cancer cells. Notably, we observed differential expression patterns among different gynaecological cancer types and stages, indicating potential associations with tumour aggressiveness and patient prognosis. Furthermore, CRH peptides were found to exert significant influences on critical cellular processes, such as cell proliferation, migration, invasion, and immune response, in gynaecological cancers. These findings highlight the multifaceted roles of CRH family peptides in gynaecological malignancies and emphasize the need for further research in this field. Therefore, understanding the mechanisms underlying the involvement of CRH family peptides in tumourigenesis may open new avenues for targeted therapeutic strategies in gynaecological malignancies.
keywords:

CRH, stress, gynaecological cancer, cervical cancer, breast cancer, endometrial cancer
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