The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Jan-Hendrik Maiwald; Susanne Sprung; Piotr Czapiewski; Wiebke Lessel; Anna Scherping; Dirk Schomburg; Markus Plaumann; Bartłomiej Tomasik; Gerhard Behre; Johannes Haybaeck; Atanas Ignatov; Holm Eggemann; Norbert Nass

doi:10.5114/wo.2021.110010

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2021
vol. 25

Send email

Copy url:

abstract:

Original paper

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Jan-Hendrik Maiwald

¹

,

Susanne Sprung

²

,

Piotr Czapiewski

^{1, 3}

,

Wiebke Lessel

¹

,

Anna Scherping

¹

,

Dirk Schomburg

⁴

,

Markus Plaumann

⁴

,

Bartłomiej Tomasik

^{5, 6}

,

Gerhard Behre

⁷

,

Johannes Haybaeck

^{1, 2, 8, 9}

,

Atanas Ignatov

¹⁰

,

Holm Eggemann

¹¹

,

Norbert Nass

^{1, 7}

Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria
Department of Pathology, Dessau Medical Centre, Dessau, Germany
Institute for Biometrics and Medical Informatics, Otto von Guericke University Magdeburg, Magdeburg, Germany
Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Clinic for Internal Medicine I, Dessau Medical Centre, Dessau, Germany
Diagnostic & Research Centre for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, Graz, Austria
Center for Biomarker Research in Medicine, Graz, Austria
Department of Obstetrics and Gynaecology, Otto von Guericke University Magdeburg, Magdeburg, Germany
Department of Obstetrics and Gynaecology, Hospital Magdeburg GmbH, Magdeburg, Germany

Contemp Oncol (Pozn) 2021; 25 (3): 204–212

DOI: https://doi.org/10.5114/wo.2021.110010

Online publish date: 2021/10/14

View full text Get citation

PlumX metrics:

Introduction
The G protein-coupled oestrogen receptor 1 (GPER-1) is a potential prognostic marker in breast cancer. However, its role in male breast cancer (MBC) is still unknown. This study evaluates the expression of GPER-1 in MBC samples and correlates these data with clinical and pathological parameters including patients’ survival.

Material and methods
For this retrospective analysis of a prospectively maintained cohort of patients with MBC, we examined 161 specimens for GPER-1 expression using immunohistochemistry. An immunoreactive score (IRS) was calculated based on staining intensity and the percentage of positive tumour cells. Then, we correlated GPER-1 IRS with clinical and pathological parameters, and overall and relapse-free survival.

Results
About 40% of MBC samples were positive for GPER-1 expression (IRS ≥ 4). There was no significant correlation with clinicopathological parameters, such as hormone receptor status or grading. However, a statistical trend was observed for tumour size (≥ 2 cm, p = 0.093). Kaplan-Meier survival analysis revealed no significant correlation with relapse-free survival. However, there was a significant correlation with overall survival, but when we adjusted the log-rank p-value to compensate for the cut-off point optimization method, it rose above 0.1. Additionally, GPER-1-positive patients were older at diagnosis. When adjusted for age by multivariable Cox regression analysis, the significance of GPER-1 status for survival was further reduced.

Conclusions
We found no significant prognostic value of GPER-1 in this MBC cohort as anticipated from studies on female BC. Future studies with higher sample size are needed to further verify a potential sex-specific role of GPER-1.

keywords:

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Jan-Hendrik Maiwald 1 , Susanne Sprung 2 , Piotr Czapiewski 1, 3 , Wiebke Lessel 1 , Anna Scherping 1 , Dirk Schomburg 4 , Markus Plaumann 4 , Bartłomiej Tomasik 5, 6 , Gerhard Behre 7 , Johannes Haybaeck 1, 2, 8, 9 , Atanas Ignatov 10 , Holm Eggemann 11 , Norbert Nass 1, 7

male breast cancer, MBC, survival analysis, GPER-1, GPR30, OS, RFS