eISSN: 2300-6722
ISSN: 1899-1874
Medical Studies/Studia Medyczne
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
4/2021
vol. 37
 
Share:
Share:
abstract:
Review paper

The importance of acute-phase proteins as markers in cancers

Paulina Zegarska
1
,
Urszula Markowska
2
,
Małgorzata Płoszaj
3

  1. Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, Warsaw, Poland
  2. Department Historical and Educational Sciences, Institute of Psychology, University of Wroclaw, Warsaw, Poland
  3. Institute of Psychology, Pedagogical University, Krakow, Poland
Medical Studies/Studia Medyczne 2021; 37 (4): 344–348
Online publish date: 2021/12/31
View full text Get citation
 
PlumX metrics:
Acute-phase proteins (APPs) form a group of heterogeneous proteins whose synthesis takes place in the liver. This involves mediators such as cytokines and constitutes a response to acute inflammations, bacterial infections, tumours, and autoimmune diseases. C-reactive protein is among the most important APPs. It participates in cancerous processes, especially in colon and rectal cancer. Another APP is haptoglobin. This glycoprotein prevents iron loss and kidney damage, and is associated with diagnostic neoplastic progression connected with fucosylation. Fucoso–haptoglobin is a highly effective marker for prognosis because an increased concentration of this complex is indicative of the distant metastases amount. Another APP is acidic -glycoprotein (AGP), which increases to a serious level during acute inflammations and tumour-promoting processes. Its protective role involves platelet aggregation inhibition and chemotactic activity. The purpose of this study was to review the role of selected acute phase proteins in cancer promotion and progression.
keywords:

acute-phase proteins, biological tumour marker, C-reactive protein, tumour necrosis factor-α, haptoglobins

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.