The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion

Yakup Düzköprü; Zeynep Oruç; Muhammet A. Kaplan; Refik Ülkü; Çetin Tanrıkulu; Derya Esmer; Ali Bırak; Mehmet Küçüköner; Zuhat Urakçı; Abdurrahman Işıkdoğan

doi:10.5114/wo.2017.70111

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2017
vol. 21

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abstract:

Original paper

The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion

Yakup Düzköprü

,

Zeynep Oruç

,

Muhammet A. Kaplan

,

Refik Ülkü

,

Çetin Tanrıkulu

,

Derya Esmer

,

Ali Bırak

,

Mehmet Küçüköner

,

Zuhat Urakçı

,

Abdurrahman Işıkdoğan

Contemp Oncol (Pozn) 2017; 21 (3): 213–217

DOI: https://doi.org/10.5114/wo.2017.70111

Online publish date: 2017/09/29

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AMA

Düzköprü Y, Oruç Z, Kaplan M, et al. The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion. Contemporary Oncology/Współczesna Onkologia. 2017;21(3):213-217. doi:10.5114/wo.2017.70111.

APA

Düzköprü, Y., Oruç, Z., Kaplan, M., Ülkü, R., Tanrıkulu, Ç.,  & Esmer, D. et al. (2017). The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion. Contemporary Oncology/Współczesna Onkologia, 21(3), 213-217. https://doi.org/10.5114/wo.2017.70111

Chicago

Düzköprü, Yakup, Zeynep Oruç, Muhammet A. Kaplan, Refik Ülkü, Çetin Tanrıkulu, Derya Esmer,  and Ali Bırak et al. 2017. "The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion". Contemporary Oncology/Współczesna Onkologia 21 (3): 213-217. doi:10.5114/wo.2017.70111.

Harvard

Düzköprü, Y., Oruç, Z., Kaplan, M., Ülkü, R., Tanrıkulu, Ç., Esmer, D., Bırak, A., Küçüköner, M., Urakçı, Z.,  and Işıkdoğan, A. (2017). The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion. Contemporary Oncology/Współczesna Onkologia, 21(3), pp.213-217. https://doi.org/10.5114/wo.2017.70111

MLA

Düzköprü, Yakup et al. "The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion." Contemporary Oncology/Współczesna Onkologia, vol. 21, no. 3, 2017, pp. 213-217. doi:10.5114/wo.2017.70111.

Vancouver

Düzköprü Y, Oruç Z, Kaplan M, Ülkü R, Tanrıkulu Ç, Esmer D et al. The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion. Contemporary Oncology/Współczesna Onkologia. 2017;21(3):213-217. doi:10.5114/wo.2017.70111.

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Aim of the study: Vascular endothelial growth factor (VEGF) is one of the parameters that has been studied in differential diagnosis of malignant fluids. This study is aimed at evaluate applicability of serum, fluid VEGF level and fluid to serum VEGF ratio in the diagnosis of malignant pleural mesothelioma (MPM).

Material and methods: The patients with pleural effusion over age of 18, between 2011 and 2015 were included in the study. They were divided into three groups: group 1 – mesothelioma patients; group 2 – other malignancies; and group 3 – benign aetiologies. Group 1 and 2 were termed as the malignant group. Fluid, serum VEGF levels, and the ratio of fluid/serum VEGF level were studied to evaluate the fluid/serum VEGF ratio in all groups.

Results: Twenty cases with mesothelioma, 44 cases with other malignancies, and 20 cases with benign aetiologies were included in this study. No statistically significant difference was found according to serum VEGF levels for all groups, (group 1: 437 ±324 pg/ml, group 2: 354 ±223 pg/ml, group 3: 373 ±217 pg/ml, p = 0.836), while fluid VEGF levels showed a statistically significant difference (group 1: 3359 ±700 pg/ml, group 2: 2175 ±435 pg/ml, group 3: 1092 ±435 pg/ml, p = 0.041). The ratio of fluid to serum VEGF levels showed a difference, at the significance limit, between the malignant (group 1 and group 2) and benign (group 3) groups (8.83 ±1.29 vs. 4.57 ±1.07, p = 0.059) but showed a statistically significant difference between the mesothelioma and benign groups (12.11 ±1.68 vs. 4.57 ±1.07, p = 0.044).

Conclusions: The VEGF fluid/serum ratio may be an applicable parameter in the differential diagnosis of malignant fluids, especially MPM.

keywords:

The importance of serum and pleural fluid level of vascular endothelial growth factor (VEGF) and VEGF fluid/serum ratio in the differential diagnosis of malignant mesothelioma-related pleural effusion

Yakup Düzköprü , Zeynep Oruç , Muhammet A. Kaplan , Refik Ülkü , Çetin Tanrıkulu , Derya Esmer , Ali Bırak , Mehmet Küçüköner , Zuhat Urakçı , Abdurrahman Işıkdoğan

pleural effusion, vascular endothelial growth factor (VEGF), malignant mesothelioma, pleural fluid/serum VEGF ratio

Yakup Düzköprü

,

Zeynep Oruç

,

Muhammet A. Kaplan

,

Refik Ülkü

,

Çetin Tanrıkulu

,

Derya Esmer

,

Ali Bırak

,

Mehmet Küçüköner

,

Zuhat Urakçı

,

Abdurrahman Işıkdoğan