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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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5/2023
vol. 40
 
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abstract:
Original paper

The importance of specific IgE antibodies in the epidemiology of allergic rhinitis and asthma (ECAP survey): part five. The relationship between the concentration of specific IgE antibodies in serum and types of rhinitis

Andrzej Namysłowski
1
,
Agnieszka Lipiec
1
,
Wojciech Zieliński
1, 2
,
Filip Raciborski
1
,
Edyta Krzych-Fałta
1
,
Krzysztof Samoliński
3
,
Anna Szylling
4
,
Bolesław Samoliński
1

  1. Department of the Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland
  2. Department of Econometrics and Statistics, Warsaw University of Life Sciences, Warsaw, Poland
  3. Department of Emergency Medical Services, Medical University of Warsaw, Warsaw, Poland
  4. Department of Allergology and Clinical Immunology of the Central Clinical Hospital, Warsaw, Poland
Adv Dermatol Allergol 2023; XL (5): 617-624
DOI: https://doi.org/10.5114/ada.2023.130314
Online publish date: 2023/08/04
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Introduction:
Specific immunoglobulins E (sIgE) are important parameters for the estimation of severity of allergic diseases.

Aim:
To determine the relationship between the concentration of specific IgE antibodies in serum and types of rhinitis.

Material and methods:
The concentration of sIgE antibodies against allergens Dermatophagoides pteronyssinus, cat dander, timothy grass, and Alternaria alternata were determined in the serum of 4077 respondents randomly selected from 8 regions (ECAP study). The positive results of sIgE (≥ 0.35 IU/ml or ≥ 0.7 IU/ml) were correlated to clinical diagnosis (types of rhinitis, skin-prick tests).

Results:
sIgE antibodies are more frequently detected in respondents with intermittent/seasonal allergic rhinitis and a negative skin-prick test as compared to healthy respondents with a negative skin-prick test (p < 0.05 to p < 0.001). Relating to allergens of D. pteronyssinus and cat dander, sIgE antibodies are more frequently detected in respondents with persistent/perennial allergic rhinitis and a negative or weakly positive skin-prick test as compared to healthy respondents with a negative or weakly positive skin-prick test (p < 0.05 to p < 0.001).

Conclusions:
The occurrence of intermittent/seasonal allergic rhinitis is much more probable in respondents with a negative skin-prick test, when IgE antibodies against the same allergen are detected. And the occurrence of persistent/perennial allergic rhinitis is much more probable in respondents with a negative or weakly positive skin-prick test with allergens of D. pteronyssinus or cat dander, when IgE antibodies against the same allergen are detected.

keywords:

specific immunoglobulins E, skin-prick test, allergic rhinitis, ECAP
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