eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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4/2016
vol. 2
 
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abstract:
Original paper

The influence of anti-HBc status on the sustained virological response rate in HCV-infected patients treated with pegylated interferon alfa 2 and ribavirin

Anna Szymanek-Pasternak
,
Krzysztof A. Simon
,
Sylwia Serafińska
,
Justyna Janocha-Litwin
,
Monika Pazgan-Simon
,
Grzegorz Madej

Clin Exp HEPATOL 2016; 2, 4: 155–160
DOI: https://doi.org/10.5114/ceh.2016.63873
Online publish date: 2016/11/28
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Aim of the study: To determine the influence of HBsAg and HBeAg negative but anti-HBc positive status on the sustained virological response (SVR) rate in HCV-infected patients treated with pegylated interferon alfa 2 (Peg-IFNα-2) and ribavirin (RBV).

Material and methods: The study was based on the retrospective analysis of medical records of HCV-infected patients who started Peg-IFNα and RBV treatment between 1 January 2011 and 31 December 2013 at the 1st and 2nd Department of Infectious Diseases of the Regional Hospital in Wrocław, Poland.

Results: Among 240 patients included in the analysis 99 were anti-HBc positive and 141 anti-HBc negative. In the genotype 1, anti-HBc positive group the SVR rate was 47% and in the anti-HBc negative group it was 42.7% (p = 0.591). In the genotype 3, anti-HBc positive group the SVR rate was 60% and in anti-HBc negative patients it was 63.2% (p = 0.79). Differences in SVR rates between anti-HBc positive and negative groups were not statistically significant. None of the anti-HBc positive patients developed reactivation of HBV infection during or in the 24 weeks following the end of treatment.

Conclusions: Anti-HBc determination does not seem to be useful in predicting treatment outcome of conventional Peg-IFNα/RBV therapy in patients infected with HCV genotypes 1 and 3.
keywords:

chronic hepatitis C, HCV infection, HBV occult infection
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