The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease

Magdalena Świderska; Jerzy Jaroszewicz; Agnieszka Stawicka; Anna Parfieniuk-Kowerda; Adrian Chabowski; Robert Flisiak

doi:10.5114/ceh.2017.68466

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Review paper

The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease

Magdalena Świderska

,

Jerzy Jaroszewicz

,

Agnieszka Stawicka

,

Anna Parfieniuk-Kowerda

,

Adrian Chabowski

,

Robert Flisiak

Clin Exp HEPATOL 2017; 3, 3: 127-134

DOI: https://doi.org/10.5114/ceh.2017.68466

Online publish date: 2017/06/21

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AMA

Świderska M, Jaroszewicz J, Stawicka A, Parfieniuk-Kowerda A, Chabowski A, Flisiak R. The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease. Clinical and Experimental Hepatology. 2017;3(3):127-134. doi:10.5114/ceh.2017.68466.

APA

Świderska, M., Jaroszewicz, J., Stawicka, A., Parfieniuk-Kowerda, A., Chabowski, A.,  & Flisiak, R. (2017). The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease. Clinical and Experimental Hepatology, 3(3), 127-134. https://doi.org/10.5114/ceh.2017.68466

Chicago

Świderska, Magdalena, Jerzy Jaroszewicz, Agnieszka Stawicka, Anna Parfieniuk-Kowerda, Adrian Chabowski,  and Robert Flisiak. 2017. "The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease". Clinical and Experimental Hepatology 3 (3): 127-134. doi:10.5114/ceh.2017.68466.

Harvard

Świderska, M., Jaroszewicz, J., Stawicka, A., Parfieniuk-Kowerda, A., Chabowski, A.,  and Flisiak, R. (2017). The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease. Clinical and Experimental Hepatology, 3(3), pp.127-134. https://doi.org/10.5114/ceh.2017.68466

MLA

Świderska, Magdalena et al. "The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease." Clinical and Experimental Hepatology, vol. 3, no. 3, 2017, pp. 127-134. doi:10.5114/ceh.2017.68466.

Vancouver

Świderska M, Jaroszewicz J, Stawicka A, Parfieniuk-Kowerda A, Chabowski A, Flisiak R. The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease. Clinical and Experimental Hepatology. 2017;3(3):127-134. doi:10.5114/ceh.2017.68466.

PlumX metrics:

Non-alcoholic fatty liver disease (NAFLD) is a chronic progressive liver disease, coupled with metabolic syndrome, which may progress to non-alcoholic steatohepatitis (NASH). Diabetes, obesity, hypertension, hypercholesterolemia, and hypertriglyceridemia are considered to be the most common causes leading to the incidence of NAFLD. It is assumed that the accumulation of lipid deposits in hepatocytes leads to production of proinflammatory cytokines that triggers the development of liver inflammation. Regulatory T cells (Tregs) play a critical role in regulating inflammatory processes in NASH, while T helper type 17 (Th17) might functionally oppose Treg-mediated responses. In addition, important mediators of hepatic steatosis are fatty hormones known as adipokines. We aimed to describe the significance and interaction between Treg and Th17-related cytokines as well as adipokines in pathogenesis and its potential use as biomarkers of NAFLD, especially with respect to progression to NASH.

keywords:

The interplay between Th17 and T-regulatory responses as well as adipokines in the progression of non-alcoholic fatty liver disease

Magdalena Świderska , Jerzy Jaroszewicz , Agnieszka Stawicka , Anna Parfieniuk-Kowerda , Adrian Chabowski , Robert Flisiak

NAFLD, NASH, Treg, Th17, adipokines

Magdalena Świderska

,

Jerzy Jaroszewicz

,

Agnieszka Stawicka

,

Anna Parfieniuk-Kowerda

,

Adrian Chabowski

,

Robert Flisiak