The mystery of let-7d – a small RNA with great power

Tomasz Kolenda; Weronika Przybyła; Anna Teresiak; Andrzej Mackiewicz; Katarzyna M. Lamperska

doi:10.5114/wo.2014.44467

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2014
vol. 18

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abstract:

Review paper

The mystery of let-7d – a small RNA with great power

Tomasz Kolenda

,

Weronika Przybyła

,

Anna Teresiak

,

Andrzej Mackiewicz

,

Katarzyna M. Lamperska

Contemp Oncol (Pozn) 2014; 18 (5): 293–301

DOI: https://doi.org/10.5114/wo.2014.44467

Online publish date: 2014/11/05

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miRNAs belong to a class of small non-coding RNAs which can modulate gene expression. Disturbances in their expression and function may cause cancer formation, progression and cell response to various types of stress. The let-7 family is one of the most studied groups of miRNAs. The family contains 13 members with similar sequences and a wide spectrum of target genes. In this paper, we mostly focus on one member of the family - let-7d. This miRNA is dysregulated in many types of cancers. It can be over- or down-expressed, and it acts as a tumor suppressor or oncogene. It regulates various genes such as LIN28, C-MYC, K-RAS, HMGA2 and IMP-1. Moreover, let-7d has a significant impact on epithelial-to-mesenchymal transition (EMT) and formation of cancer initiating cells which are resistant to irradiation and chemical exposure and responsible for cancer metastasis. Let-7d can serve as a prognostic and predictive marker for personalization of the treatment. Let-7d is a small RNA with great power, but in different cell genetic backgrounds it acts in different ways, which makes this molecule still mysterious.

keywords:

The mystery of let-7d – a small RNA with great power

Tomasz Kolenda , Weronika Przybyła , Anna Teresiak , Andrzej Mackiewicz , Katarzyna M. Lamperska

let-7d, let-7 family, miRNA, gene regulation, cancer, radiotherapy, chemotherapy

Tomasz Kolenda

,

Weronika Przybyła

,

Anna Teresiak

,

Andrzej Mackiewicz

,

Katarzyna M. Lamperska