eISSN: 2353-9461
ISSN: 0860-7796
BioTechnologia
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2/2016
vol. 97
 
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abstract:
SHORT COMMUNICATIONS

The new RNAi-based therapy for brain tumors

Katarzyna Rolle
1
,
Jan Barciszewski
1

  1. Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland
BioTechnologia vol. 97(2) C pp. 153-155 C 2016
Online publish date: 2016/07/20
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The subject matter of this invention includes a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA intervention (iRNAi); the use of a sequence of double-stranded RNA: ATN-RNA, a method of treating (a) brain tumor and a method of inhibiting brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein ubiquitously expressed by malignant gliomas, which probably contributes to the tumor cell adhesion, invasion, migration, and proliferation. For tenascin-C inhibition, the iRNAi approach has been applied.


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