The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

Agnieszka Karbownik; Edyta Szałek; Hanna Urjasz; Aleksandra Głęboka; Emilia Mierzwa; Edmund Grześkowiak

doi:10.5114/wo.2012.31775

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

5/2012
vol. 16

Send email

Copy url:

abstract:

Original paper

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

Agnieszka Karbownik

,

Edyta Szałek

,

Hanna Urjasz

,

Aleksandra Głęboka

,

Emilia Mierzwa

,

Edmund Grześkowiak

Wspolczesna Onkol 2012; 16 (5): 435–439

DOI: https://doi.org/10.5114/wo.2012.31775

Online publish date: 2012/11/20

View full text Get citation

PlumX metrics:

Aim of the study: The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days.

Material and methods: Original vials of cisplatin injection (1 mg/ml, Teva) were stored at room temperature and subjected to re-piercing after 1, 2, 3, 7, 14, 21, 28 and 30 days following the initial piercing. Cisplatin infusions at nominal concentrations of 0.1 mg/ml were prepared in 0.9% sodium chloride (1000 ml) in PE bags. Chemical stability was measured by means of a stability-indicating high-performance liquid chromatography (HPLC) assay. Physical stability was assessed by visual inspection in normal light.

Results: The concentration of cisplatin at each sampling time in the analysed solutions remained within 92.0–100.7% of initial concentration, regardless of the container. No changes in colour or turbidity were observed in any of the vials or prepared solutions.

Conclusions: Cisplatin, both undiluted in glass containers and diluted with NaCl 0.9% in PE bags, remains stable (< 10% degradation) for at least 30 days at room temperature when protected from light.

keywords:

The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%

Agnieszka Karbownik , Edyta Szałek , Hanna Urjasz , Aleksandra Głęboka , Emilia Mierzwa , Edmund Grześkowiak

cisplatin, stability, concentrate, infusion

Agnieszka Karbownik

,

Edyta Szałek

,

Hanna Urjasz

,

Aleksandra Głęboka

,

Emilia Mierzwa

,

Edmund Grześkowiak