The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population

Beata Kaleta; Piotr Mróz; Andrzej Górski; Jacek Łukaszkiewicz; Anna Woźniacka; Jarosław Bogaczewicz

doi:10.5114/ada.2019.83499

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population

Beata Kaleta

¹

,

Piotr Mróz

²

,

Andrzej Górski

¹

,

Jacek Łukaszkiewicz

²

,

Anna Woźniacka

³

,

Jarosław Bogaczewicz

³

Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland
Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Warsaw, Poland
Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland

Adv Dermatol Allergol 2020; XXXVII (2): 190–194

DOI: https://doi.org/10.5114/ada.2019.83499

Online publish date: 2020/05/05

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AMA

Kaleta B, Mróz P, Górski A, Łukaszkiewicz J, Woźniacka A, Bogaczewicz J. The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):190-194. doi:10.5114/ada.2019.83499.

APA

Kaleta, B., Mróz, P., Górski, A., Łukaszkiewicz, J., Woźniacka, A.,  & Bogaczewicz, J. (2020). The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), 190-194. https://doi.org/10.5114/ada.2019.83499

Chicago

Kaleta, Beata, Piotr Mróz, Andrzej Górski, Jacek Łukaszkiewicz, Anna Woźniacka,  and Jarosław Bogaczewicz. 2020. "The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (2): 190-194. doi:10.5114/ada.2019.83499.

Harvard

Kaleta, B., Mróz, P., Górski, A., Łukaszkiewicz, J., Woźniacka, A.,  and Bogaczewicz, J. (2020). The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), pp.190-194. https://doi.org/10.5114/ada.2019.83499

MLA

Kaleta, Beata et al. "The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 2, 2020, pp. 190-194. doi:10.5114/ada.2019.83499.

Vancouver

Kaleta B, Mróz P, Górski A, Łukaszkiewicz J, Woźniacka A, Bogaczewicz J. The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):190-194. doi:10.5114/ada.2019.83499.

Introduction
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease caused by genetic, environmental, and still unknown factors which lead to deregulation of the immune system. Osteopontin (OPN) is a multifunctional glycoprotein, expressed in various cell types, and found to play key roles in immunity. OPN and variants of the OPN gene are involved in inflammatory conditions, however, their role in SLE are controversial.

Aim
To investigate the frequency of single nucleotide polymorphism (SNP) rs1126616 (707 C/T) variants in the OPN gene and its associations with SLE manifestations in Polish patients.

Material and methods
The study population consisted of 83 SLE patients and 100 gender-, age- and ethnically matched healthy controls. DNA was extracted from whole blood samples using the standard procedure. Genotyping was performed by real-time polymerase chain reaction (RT-PCR). The association between clinical features of SLE and 707 C/T genotypes was determined.

Results
The mutant (CT, TT) genotypes were observed more frequently than the wild-type (CC) genotype in SLE patients compared to controls (p = 0.037). However, no association between 707 C/T variants and SLE clinical manifestations or laboratory parameters was found.

Conclusions
The present data suggest that CT and TT genotypes of OPN 707 C/T SNP are associated with a higher SLE risk, but do not affect the clinical course of the disease in the Polish population.

keywords:

The preliminary association study of osteopontin 707 C/T polymorphism with systemic lupus erythematosus in a Polish population

Beata Kaleta 1 , Piotr Mróz 2 , Andrzej Górski 1 , Jacek Łukaszkiewicz 2 , Anna Woźniacka 3 , Jarosław Bogaczewicz 3

gene, osteopontin, polymorphism, systemic lupus erythematosus

Beata Kaleta

¹

,

Piotr Mróz

²

,

Andrzej Górski

¹

,

Jacek Łukaszkiewicz

²

,

Anna Woźniacka

³

,

Jarosław Bogaczewicz

³