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ISSN: 1233-9687
Polish Journal of Pathology
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2/2020
vol. 71
 
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abstract:
Original paper

The prognostic relationship between histopathological and immunohistochemical features of hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed type

Fatmagül Kuşku Çabuk
1
,
Nuray Başsüllü
1
,
İlknur Türkmen
1
,
Murat Dayangaç
2
,
Murat Akyıldız
3
,
Yıldıray Yüzer
2
,
Yaman Tokat
2
,
Gülen Bülbül Doğusoy
1

  1. Department of Pathology, İstanbul Bilim University, İstanbul, Turkey
  2. Department of Hepatobiliary and Organ Transplant Center, Şişli Florence Nigthingale Hospital İstanbul, Turkey
  3. Department of Gastroentorology, İstanbul Bilim University, İstanbul, Turkey
Pol J Pathol 2020; 71 (2): 79-86
DOI: https://doi.org/10.5114/pjp.2020.97015
Online publish date: 2020/07/21
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Hepatocellular carcinoma, intrahepatic cholangiocarcinoma, and combined hepatocellular and cholangiocarcinoma are the most common cancers of the liver. In this study, our first aim is to evaluate the relationship between prognosis and clinicopathological parameters. The second aim involves investigating the need for immunohistochemical staining and patterns of tumours to differentiate between them.

Sixty-one cases were included in this study. For IHC, we used Hep par-1, CK7, CK19, CD56 and p53 staining, and the patterns of tumours were evaluated in haematoyxylin-eosin sections.

No significant differences were found in Kaplan-Meier life analysis between the tumour types and OS and DFS values, but these values were greater in HCC than in ICC. There were no relationships between clinicopathologic parameters and OS and DFS. Although the multifocality, stage and grade of tumour were higher in HCC than in ICC, the perineural invasion and lymph node metastasis were more common in ICC than in HCC.

The diagnosis was changed in 4 cases, from HCC to ICC in one case and to combined type in 3 cases after IHC. Pathologist should be alert to mixed patterns in terms of diagnosis and IHC, because it helps differential diagnosis in these cases.
keywords:

hepatocellular carcinoma, liver neoplasms, cholangiocarcinoma, risk factors
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