eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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2/2017
vol. 14
 
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abstract:
Original paper

The prognostic value of carcinoembryonic antigen levels in blood and intraoperative pleural lavage fluid in non-small-cell lung cancer

Tevfik Ilker Akcam
,
Ufuk Cagirici
,
Ayse Gul Ergonul
,
Ali Ozdil
,
Onder Kavurmaci
,
Kutsal Turhan
,
Alpaslan Cakan
,
Burcu Barutcuoglu

Kardiochirurgia i Torakochirurgia Polska 2017; 14 (2): 104-109
DOI: https://doi.org/10.5114/kitp.2017.68740
Online publish date: 2017/07/05
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Introduction: There is no specific marker for lung cancer, but, in some lung cancer types, carcinoembryonic antigen (CEA) can reach high levels in the blood and pleural fluid.

Aim: This study investigated the relationship of CEA levels in blood (CEAB) and intraoperative pleural lavage fluid (CEAP) in non-small-cell lung cancer (NSCLC) with the type, stage, and extent of lung cancer.

Material and methods: A total of 50 patients, who underwent surgery at our clinic due to NSCLC (group I) or benign lung pathology (group II), were assessed. For this prospectively designed study, 25 consecutive patients were included in each group, and their CEAB and CEAP levels were investigated.

Results: When the levels of CEAP were compared, the average value of group I (1.35 ng/ml) was significantly higher than the average value of group II (0.04 ng/ml) (p = 0.027). When CEA levels were examined separately, and average values were taken according to surgical pathology results, both CEAB and CEAP levels of adenocarcinoma patients were found to be higher than those of the other groups. This difference was only significant for the level of CEAP (p = 0.026).

Conclusions: Although the average CEAB levels of patients with adenocarcinoma were higher than those of patients with other histopathological types, this difference was not statistically significant. However, we found that CEAP levels were significantly higher in patients with adenocarcinoma. These results have led us to consider that CEAP elevation is a more sensitive marker than the elevation of CEAB.
keywords:

carcinoembryonic antigen, non-small-cell lung cancer, pleural lavage
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