eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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3/2020
vol. 15
 
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abstract:
Review paper

The relationship between IL-6 and thrombocytosis accompanying gastrointestinal tumours

Valéria Jósa
1
,
Valentin Brodszky
2
,
Attila Zaránd
3
,
Tünde Mezei
4
,
Zsuzsanna Szilasi
5
,
Keresztély Merkel
6
,
Adrienne Fehér
7
,
Zoltán Szállási
8
,
Zsolt Baranyai
3

  1. Department of Otorhinolaryngology and Head and Neck Surgery, Flór Ferenc Hospital, Kistarcsa, Hungary
  2. Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
  3. 1st Department of Surgery, Semmelweis University Budapest, Budapest, Hungary
  4. Department of Urology, Jahn Ferenc, Budapest, Hungary
  5. Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, Budapest, Hungary
  6. Department of Surgery, Szent Imre Hospital, Budapest, Hungary
  7. Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary
  8. Computational Health Informatics Program (CHIP), Harvard Medical School, Boston, USA
Gastroenterology Rev 2020; 15 (3): 215–219
DOI: https://doi.org/10.5114/pg.2020.98538
Online publish date: 2020/09/19
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Introduction
Several reports have stated that thrombocytosis is associated with worse survival and higher rate of metastasis in solid tumours. A study in ovarian tumours implicated IL-6 produced by tumour cells as a key mechanistic factor.

Aim
To evaluate the relevance of this paraneoplastic pathway in gastrointestinal cancer.

Material and methods
After excluding thromboembolic and inflammatory disorders, 161 patients were enrolled who had been operated due to various gastrointestinal cancer at the 1st Department of Surgery at the Semmelweis University between 2015 and 2017. Platelet counts and serum IL-6 levels were determined from preoperative blood samples. Thrombocytosis was defined as the upper limit of normal platelet count, e.g. 400 × 103/μl.

Results
A weak but significantly positive correlation was found between elevated platelet counts and serum IL-6 (correlation coefficient: R = 0.214, p = 0.006), which became more pronounced in colon and oesophageal cancer if evaluated in the different tumour types (R = 0.292 and R = 0.419, respectively). However, using a multivariant linear regression model (R2 = 0.47) corrected with haemoglobin, white blood cell count, and advanced disease stage, the analysis showed no significant correlation between serum IL-6 and platelet counts.

Conclusions
In gastrointestinal cancer our study did not support the paracrine-mediated paraneoplastic pathway described in ovarian tumors. Thrombocytosis showed significant correlation with white blood cells instead of serum IL-6, which implies that the inflammatory process may influence both parameters. Further studies are needed on larger patient cohorts.

keywords:

thrombocytosis, IL-6, gastrointestinal tumours, paraneoplastic pathway
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