The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?

Esra Pasaoglu; Cem Leblebici; Oguzhan Okcu; Ceren Boyaci; Nevra Dursun; Aytul Hande Yardimci; Meltem Kucukyilmaz

doi:10.5114/pjp.2016.62829

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

4/2016
vol. 67

Send email

Copy url:

abstract:

Original paper

The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?

Esra Pasaoglu

,

Cem Leblebici

,

Oguzhan Okcu

,

Ceren Boyaci

,

Nevra Dursun

,

Aytul Hande Yardimci

,

Meltem Kucukyilmaz

Pol J Pathol 2016; 67 (4): 376-383

DOI: https://doi.org/10.5114/pjp.2016.62829

Online publish date: 2016/11/28

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Pasaoglu E, Leblebici C, Okcu O, et al. The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?. Polish Journal of Pathology. 2016;67(4):376-383. doi:10.5114/pjp.2016.62829.

APA

Pasaoglu, E., Leblebici, C., Okcu, O., Boyaci, C., Dursun, N.,  & Hande Yardimci, A. et al. (2016). The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?. Polish Journal of Pathology, 67(4), 376-383. https://doi.org/10.5114/pjp.2016.62829

Chicago

Pasaoglu, Esra, Cem Leblebici, Oguzhan Okcu, Ceren Boyaci, Nevra Dursun, Aytul Hande Yardimci,  and Meltem Kucukyilmaz. 2016. "The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?". Polish Journal of Pathology 67 (4): 376-383. doi:10.5114/pjp.2016.62829.

Harvard

Pasaoglu, E., Leblebici, C., Okcu, O., Boyaci, C., Dursun, N., Hande Yardimci, A.,  and Kucukyilmaz, M. (2016). The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?. Polish Journal of Pathology, 67(4), pp.376-383. https://doi.org/10.5114/pjp.2016.62829

MLA

Pasaoglu, Esra et al. "The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?." Polish Journal of Pathology, vol. 67, no. 4, 2016, pp. 376-383. doi:10.5114/pjp.2016.62829.

Vancouver

Pasaoglu E, Leblebici C, Okcu O, Boyaci C, Dursun N, Hande Yardimci A et al. The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?. Polish Journal of Pathology. 2016;67(4):376-383. doi:10.5114/pjp.2016.62829.

PlumX metrics:

Prevalences of diverticulum and low-grade mucinous neoplasm (LGMN) were reported as 0.04-2% and less than 1% in the appendix. In this study, the frequency of diverticulum in LGMN cases, the relationship between diverticula and periappendicular mucin, and the possible role of diverticula in pseudomyxoma peritonei pathogenesis were researched.

Through systematic review and targeted search, 38 LGMN and 96 diverticula were identified, frequencies and relationship between diverticulum and LGMN were analysed.

Diverticulum and LGMN were determined in 4.8% and 1.04%, respectively, of 1922 appendectomy materials specifically grossed by the same pathologist. The prevalence of diverticulum was higher in our study than literature. The difference may be due to detailed macroscopic examination. Diverticulum was detected in 60% of LGMN cases. The rate of diverticulum was found to be significantly higher in LGMNs than non-neoplastic diverticulum (p < 0.001). Periappendicular mucin deposition was significantly more frequent in LGMN cases with diverticulum than in other groups (p < 0.05). Follow-ups were available in 18 patients; none of them had mucin deposition in the peritoneal cavity.

We detected that periappendicular mucin was highly associated with diverticula in LGMN cases. Periappendicular acellular mucin deposition may not give rise to pseudomyxoma peritonei. We may think that mucin could move out of the appendix through the diverticulum rather than neoplastic spread in some of these cases.

keywords:

The relationship between diverticula and low-grade mucinous neoplasm of the appendix. Does the diverticulum play a role in the development of periappendicular mucin deposition or pseudomyxoma peritonei?

Esra Pasaoglu , Cem Leblebici , Oguzhan Okcu , Ceren Boyaci , Nevra Dursun , Aytul Hande Yardimci , Meltem Kucukyilmaz

low-grade mucinous neoplasm, appendix, diverticulum

Esra Pasaoglu

,

Cem Leblebici

,

Oguzhan Okcu

,

Ceren Boyaci

,

Nevra Dursun

,

Aytul Hande Yardimci

,

Meltem Kucukyilmaz