The relationship between vitamin D and adolescents’ parathyroid hormone
and bone mineral density

Ainur Donayeva; Ainur Amanzholkyzy; Ibrahim A. Abdelazim; Saule Rakhyzhanova; Akzhunus Mannapova; Talgar Abilov; Zaituna Khamidullina; Karlygash Bimagambetova; Gulnara Gubasheva; Dinara Kulzhanova; Akbayan Turesheva; Samat Saparbayev

doi:10.5114/pm.2024.136327

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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1/2024
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abstract:

Original paper

The relationship between vitamin D and adolescents’ parathyroid hormone and bone mineral density

Ainur Donayeva

¹

,

Ainur Amanzholkyzy

¹

,

Ibrahim A. Abdelazim

²

,

Saule Rakhyzhanova

³

,

Akzhunus Mannapova

⁴

,

Talgar Abilov

¹

,

Zaituna Khamidullina

⁵

,

Karlygash Bimagambetova

¹

,

Gulnara Gubasheva

⁶

,

Dinara Kulzhanova

¹

,

Akbayan Turesheva

¹

,

Samat Saparbayev

¹

Department of Normal Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynaecology, Faculty of Medicine Ain Shams University, Cairo, Egypt
Department of Physiological Disciplines, Named after T.A. Nazarova, NCJSC, Semey Medical University, Semey, Kazakhstan
Department of Neurology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Obstetrics and Gynaecology №1, Astana Medical University, Astana, Kazakhstan
Department of Obstetrics and Gynaecology №2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Menopause Rev 2024; 23(1): 1-5

DOI: https://doi.org/10.5114/pm.2024.136327

Online publish date: 2024/03/17

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Introduction
To detect the relationship between 25-hydroxy vitamin D (25(OH)D) and adolescents’ parathyroid hormone (PTH) and bone mineral density (BMD).

Material and methods
Two hundred adolescent girls were recruited for this cross-sectional comparative study. After detailed evaluation, a pelvic sonography was performed for the studied adolescents to rule out any pelvic pathology. Adolescents’ blood samples were collected to measure the thyroid stimulating hormone, prolactin, glycosylated haemoglobin (HbA1C), PTH, and 25(OH)D. The studied adolescents’ BMD and the T-score were evaluated at 2 anatomical sites. The studied adolescents were classified according to their serum 25(OH)D into 2 groups: a 25(OH)D-deficient group (study group; 25(OH)D < 20 ng/ml) and normal controls (25(OH)D > 30 ng/ml). Student’s t-test was used for analysis of the studied adolescents’ variables, and correlation analysis (Pearson`s correlation) was used to detect the relationship between 25(OH)D and adolescents’ PTH and BMD.

Results
The parathyroid hormone was statistically higher in the 25(OH)D-deficient group than in the normal controls (41.3 ±3.4 pg/ml vs. 21.1 ±2.8) (p = 0.02), and the BMD was statistically lower in the 25(OH)D-deficient group than in the normal controls (–1.25 ±0.5 vs. 0.3 ±0.4) (p = 0.01). The 25(OH)D had a significant negative correlation with the adolescents’ PTH (r = –0.9175; p < 0.00001) and a significant positive correlation with the adolescents’ BMD (r = 0.756; p < 0.00001). The parathyroid hormone had a significant negative correlation with the adolescents’ BMD (r = –0.7006; p < 0.00001).

Conclusions
The parathyroid hormone in this study had significant negative correlations with both 25(OH)D and BMD. The 25(OH)D had a significant positive correlation with the studied adolescents’ BMD.

keywords:

The relationship between vitamin D and adolescents’ parathyroid hormone and bone mineral density

Ainur Donayeva 1 , Ainur Amanzholkyzy 1 , Ibrahim A. Abdelazim 2 , Saule Rakhyzhanova 3 , Akzhunus Mannapova 4 , Talgar Abilov 1 , Zaituna Khamidullina 5 , Karlygash Bimagambetova 1 , Gulnara Gubasheva 6 , Dinara Kulzhanova 1 , Akbayan Turesheva 1 , Samat Saparbayev 1

bone mineral density, parathyroid hormone, vitamin D