The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation

Cosphiadi Irawan; Hayatun Nufus; Lisnawati Rachmadi; Kuntjoro Harimurti; Arie Munandar; Reyhan Yunus

doi:10.5114/wo.2022.120698

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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abstract:

Original paper

The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation

Cosphiadi Irawan

¹

,

Hayatun Nufus

²

,

Lisnawati Rachmadi

³

,

Kuntjoro Harimurti

⁴

,

Arie Munandar

⁵

,

Reyhan Eddy Yunus

⁶

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Persahabatan Central General Hospital, Jakarta, Indonesia
Department of Pathological Anatomy, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Department of Radiotherapy, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia
Department of Radiology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia

Contemp Oncol (Pozn) 2022; 26 (3): 220–228

DOI: https://doi.org/10.5114/wo.2022.120698

Online publish date: 2022/10/24

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AMA

Irawan C, Nufus H, Rachmadi L, Harimurti K, Munandar A, Yunus RE. The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation. Contemporary Oncology/Współczesna Onkologia. 2022;26(3):220-228. doi:10.5114/wo.2022.120698.

APA

Irawan, C., Nufus, H., Rachmadi, L., Harimurti, K., Munandar, A.,  & Yunus, R. E. (2022). The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation. Contemporary Oncology/Współczesna Onkologia, 26(3), 220-228. https://doi.org/10.5114/wo.2022.120698

Chicago

Irawan, Cosphiadi, Hayatun Nufus, Lisnawati Rachmadi, Kuntjoro Harimurti, Arie Munandar,  and Reyhan E Yunus. 2022. "The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation". Contemporary Oncology/Współczesna Onkologia 26 (3): 220-228. doi:10.5114/wo.2022.120698.

Harvard

Irawan, C., Nufus, H., Rachmadi, L., Harimurti, K., Munandar, A.,  and Yunus, R. (2022). The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation. Contemporary Oncology/Współczesna Onkologia, 26(3), pp.220-228. https://doi.org/10.5114/wo.2022.120698

MLA

Irawan, Cosphiadi et al. "The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation." Contemporary Oncology/Współczesna Onkologia, vol. 26, no. 3, 2022, pp. 220-228. doi:10.5114/wo.2022.120698.

Vancouver

Irawan C, Nufus H, Rachmadi L, Harimurti K, Munandar A, Yunus R. The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation. Contemporary Oncology/Współczesna Onkologia. 2022;26(3):220-228. doi:10.5114/wo.2022.120698.

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Introduction
The incidence of nasopharyngeal cancer (NPC) is high, with new cases accounting for 5.2% of all malignancies in Indonesia. Most cases are detected at an advanced stage, and recurrences are common. Vascular endothelial growth factor (VEGF) and osteopontin (OPN) are important markers in tumorigenesis that serve as prognostic predictors. This study aims to determine the correlation of VEGF and OPN expression with 3-year progression-free survival (PFS).

Material and methods
This retrospective cohort study analyzed 155 patients with locally advanced NPC. Data were obtained from medical records between 2015 and 2017. The locally advanced sample of this disease that met the inclusion criteria was stained with H&E before being prepared in a paraffin block. Furthermore, the immunohistochemistry staining results for VEGF and OPN were observed with ImageJ 1.50i and calculated semi-quantitatively using the histoscore.

Results
The 3-year PFS obtained was 39%, with a median of 23 months. Vascular endothelial growth factor expression was detected in 113 of 155 samples (72.9%), while positive OPN expression was discovered in 99 of 155 samples (63.8%). There was a correlation between VEGF (p = 0.747) and OPN expression (p = 0.584) and 3-year PFS. Positive VEGF and OPN expression in the subgroup of patients with stage IVB and N3 tumors was related to improved 3-year PFS (p < 0.05). This was similar to the positive VEGF expression in the subgroup of patients receiving neoadjuvant chemotherapy (p < 0.05).

Conclusions
Vascular endothelial growth factor and OPN remained potential prognostic predictors in NPC. Patients with positive VEGF and OPN expression in N3, IVB, and neoadjuvant treatment had significantly improved 3-year PFS.

keywords:

The relationship of vascular endothelial growth factor and osteopontin expression with 3-year progression-free survival of locally advanced nasopharyngeal cancer patients treated with platinumbased chemoradiation

Cosphiadi Irawan 1 , Hayatun Nufus 2 , Lisnawati Rachmadi 3 , Kuntjoro Harimurti 4 , Arie Munandar 5 , Reyhan Eddy Yunus 6

nasopharyngeal carcinoma, 3-year PFS, prognostic study, biomarkers

Cosphiadi Irawan

¹

,

Hayatun Nufus

²

,

Lisnawati Rachmadi

³

,

Kuntjoro Harimurti

⁴

,

Arie Munandar

⁵

,

Reyhan Eddy Yunus

⁶