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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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4/2021
vol. 38
 
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abstract:
Original paper

The risk of endothelial and erectile dysfunctions in Behçet’s disease: a comparative analysis of mucocutaneous and systemic patient groups

Yasemin Erdem
1
,
Selcuk Erdem
2
,
Mehmet Barburoglu
3
,
Ekrem Bilal Karaayvaz
4
,
Erkingul Shugaiv
5
,
Murat Kurtuncu
5
,
Artur Salmaslioglu
3
,
Huseyin Oflaz
4
,
Afet Akdag Kose
6
,
Ates Kadioglu
2

  1. Department of Dermatology, Health Science University, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey
  2. Department of Urology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
  3. Department of Radiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
  4. Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
  5. Department of Neurology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
  6. Department of Dermatology and Venereology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
Adv Dermatol Allergol 2021; XXXVIII (4): 622–628
DOI: https://doi.org/10.5114/ada.2021.108931
Online publish date: 2021/09/17
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Introduction
Behçet’s disease (BD) is a chronic inflammatory disease which can be limited to only mucocutaneous tissues or can affect different systems of the body. Aim: To investigate the association of endothelial and erectile dysfunctions with BD, on the basis of comparative analysis between mucocutaneous and systemic BD.

Material and methods
Thirty-eight men diagnosed with BD were included in the present study. The patients were stratified into two groups as mucocutaneous BD (n = 20, MBD group), and systemic BD (n = 18, SBD group). Erectile dysfunction (ED) was assessed using the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) questionnaire. The coronary flow reserve (CFR) assessment was done for analysing endothelial dysfunction (EnD), and CFR < 2 was defined as EnD. Penile Doppler ultrasonography (PDU) was performed for ED. The demographic and clinical parameters, IIEF-EF score ED classification, CFR and PDU test findings were compared between two groups.

Results
The median age was 34 (22–52) years in the overall population, and there was no difference between two groups (p = 0.558). Time from diagnosis was significantly longer (24 vs. 102 months, p = 0.021) and the use of immunosuppressive therapies was higher (0 vs. 70.6%, p < 0.001) in the SBD group. In overall, median CFR was 1.92 (1.1–5.96), and there was no difference between two groups (1.88 vs. 1.97, p = 0.812). The percentage of patients with CFR < 2 was similar in two groups (52.6% vs. 52.9%, p = 0.985). The ED status according to IIEF-EF was similar in two groups (45% vs. 27.8%, p = 0.538) as well as according to PDU analyses (10% vs. 16.7%, p = 0.544).

Conclusions
The increased risk of endothelial, and erectile dysfunctions should be considered in men who were diagnosed with mucocutaneous and systemic BD.

keywords:

Behçet’s disease, endothelial dysfunction, erectile dysfunction, mucocutaneous, systemic
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