eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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3/2006
vol. 5
 
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abstract:

The role of E-selectin in inflammatory and atherogenic processes– the impact of hormonal therapy of the menopausal period

Grzegorz Stachowiak
,
Tomasz Stetkiewicz
,
Ireneusz Połać
,
Anna Sobczuk
,
Sławomir Jędrzejczyk
,
Tomasz Pertyński

Prz Menopauz 2006; 3: 153-158
Online publish date: 2006/07/06
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E-selectin plays a very important role in phlogistic and atherosclerotic processes of the human organism. Expression of this membrane protein is found on inflammatory endothelial cells as a result of the action of pro-inflammatory cytokines. This protein is also present on atheromatous endothelium with coexisting leucocytic infiltrations. Hormone therapy of the menopausal period favourably reduces E-selectin levels, however this effect is dependent on hormonal doses, type of estrogen and progestogen used as well as on menopausal age, accompanying illnesses and addictions of women qualified for this type of treatment.
keywords:

E-selectin, inflammation, atherosclerosis, menopause, hormone therapy
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