The role of Snail1 transcription factor in colorectal cancer progression and metastasis

Marlena Brzozowa; Marek Michalski; Grzegorz Wyrobiec; Adam Piecuch; Anna Dittfeld; Marzena Harabin-Słowińska; Dariusz Boroń; Romuald Wojnicz

doi:10.5114/wo.2014.42173

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2015
vol. 19

Send email

Copy url:

abstract:

Review paper

The role of Snail1 transcription factor in colorectal cancer progression and metastasis

Marlena Brzozowa

,

Marek Michalski

,

Grzegorz Wyrobiec

,

Adam Piecuch

,

Anna Dittfeld

,

Marzena Harabin-Słowińska

,

Dariusz Boroń

,

Romuald Wojnicz

Contemp Oncol (Pozn) 2014; 19 (4): 265–270

DOI: https://doi.org/10.5114/wo.2014.42173

Online publish date: 2015/09/28

View full text Get citation

PlumX metrics:

Snail1 is a zinc-finger transcription factor, which plays a role in colorectal cancer development by silencing E-cadherin expression and inducing epithelialmesenchymal transition (EMT). During EMT tumour cells acquire a mesenchymal phenotype that is responsible for their invasive activities. Consequently, Snail1 expression in colorectal cancer is usually associated with progression and metastasis. Some studies revealed that about 77% of colon cancer samples display Snail1 immunoreactivity both in activated fibroblasts and in carcinoma cells that have undergone EMT. Therefore, expression of this factor in the stroma may indicate how many cells possess the abilities to escape from the primary tumour mass, invade the basal lamina and colonise distant target organs. Blocking snail proteins activity has the potential to avert cancer cell metastasis by interfering with such cellular processes as remodelling of the actin cytoskeleton, migration and invasion, which are clearly associated with the aggressive phenotype of the disease. Moreover, the link between factors from the snail family and cancer stem cells suggests that inhibitory agents may also prove their potency as inhibitors of cancer recurrence.

keywords:

The role of Snail1 transcription factor in colorectal cancer progression and metastasis

Marlena Brzozowa , Marek Michalski , Grzegorz Wyrobiec , Adam Piecuch , Anna Dittfeld , Marzena Harabin-Słowińska , Dariusz Boroń , Romuald Wojnicz

Snail1, colorectal cancer, calcitriol, VDR, Wnt signalling

Marlena Brzozowa

,

Marek Michalski

,

Grzegorz Wyrobiec

,

Adam Piecuch

,

Anna Dittfeld

,

Marzena Harabin-Słowińska

,

Dariusz Boroń

,

Romuald Wojnicz