The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review

Marta Fijałkowska; Michał Bonczar; Ignacy Jastrzębski; Patryk Ostrowski; Bogusław Antoszewski; Mateusz Koziej

doi:10.5114/ada.2023.124747

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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3/2023
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abstract:

Review paper

The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review

Marta Fijałkowska

¹

,

Michał Bonczar

²

,

Ignacy Jastrzębski

²

,

Patryk Ostrowski

²

,

Bogusław Antoszewski

¹

,

Mateusz Koziej

²

Department of Plastic, Reconstructive, and Aesthetic Surgery, Second Chair of Surgery, Medical University of Lodz, Poland
Department of Anatomy, Jagiellonian University Medical College, Cracow, Poland

Adv Dermatol Allergol 2023; XL (3): 384–389

DOI: https://doi.org/10.5114/ada.2023.124747

Online publish date: 2023/02/01

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AMA

Fijałkowska M, Bonczar M, Jastrzębski I, Ostrowski P, Antoszewski B, Koziej M. The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(3):384-389. doi:10.5114/ada.2023.124747.

APA

Fijałkowska, M., Bonczar, M., Jastrzębski, I., Ostrowski, P., Antoszewski, B.,  & Koziej, M. (2023). The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(3), 384-389. https://doi.org/10.5114/ada.2023.124747

Chicago

Fijałkowska, Marta, Michał Bonczar, Ignacy Jastrzębski, Patryk Ostrowski, Bogusław Antoszewski,  and Mateusz Koziej. 2023. "The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 40 (3): 384-389. doi:10.5114/ada.2023.124747.

Harvard

Fijałkowska, M., Bonczar, M., Jastrzębski, I., Ostrowski, P., Antoszewski, B.,  and Koziej, M. (2023). The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(3), pp.384-389. https://doi.org/10.5114/ada.2023.124747

MLA

Fijałkowska, Marta et al. "The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 40, no. 3, 2023, pp. 384-389. doi:10.5114/ada.2023.124747.

Vancouver

Fijałkowska M, Bonczar M, Jastrzębski I, Ostrowski P, Antoszewski B, Koziej M. The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(3):384-389. doi:10.5114/ada.2023.124747.

Introduction:
Basal cell carcinoma (BCC) is the most common skin cancer in humans, occurring in more than 50% of Caucasians during their lifetime, with a frequency rate that is continually increasing [1, 2].

Material and methods:
We present a systematic review summarizing the role of transforming growth factor β (TGF-β), cathelicidin, and human b-defensins (HBDs) in the pathogenesis of BCC. The major online databases including PubMed, Scopus, Embase, Web of Science, Cochrane Library, and Google Scholar were searched to extract studies regarding the levels of TGF-β, HBD, and cathelicidin in BCC.

Results:
A total of 14 studies met the inclusion criteria and were included in this systematic review. There were 6 studies that included initially established levels of TGF-β in BCCs. A total of 87 BCCs were analysed, and a common result was that the TGF-β levels increase in the BCCs compared to the control groups. Analogously, 2 studies contained numerical data on HBD levels but with a different in methodology. The level of cathelicidin was established in 108 BCCs and was significantly higher in the BCC group than in the control group.

Conclusions:
The presented review shows evidence that proteins like TGF-β, HBD, and cathelicidin play a role in developing BCC. Protein levels or their expression are elevated in patients with BCC. Furthermore, a critical review of the literature was presented and discussed, highlighting its shortcomings.

keywords:

The role of TGF-β and antimicrobial peptides in basal cell carcinoma: a systematic review

Marta Fijałkowska 1 , Michał Bonczar 2 , Ignacy Jastrzębski 2 , Patryk Ostrowski 2 , Bogusław Antoszewski 1 , Mateusz Koziej 2

transforming growth factor β, antimicrobial peptide, cathelicidin, human β-defensin

Marta Fijałkowska

¹

,

Michał Bonczar

²

,

Ignacy Jastrzębski

²

,

Patryk Ostrowski

²

,

Bogusław Antoszewski

¹

,

Mateusz Koziej

²