The role of antimicrobial peptides in skin tumorigenesis

Małgorzata Marcinkiewicz; Sławomir Majewski

doi:10.5114/dr.2016.59139

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2016
vol. 103

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abstract:

Review paper

The role of antimicrobial peptides in skin tumorigenesis

Małgorzata Marcinkiewicz

,

Sławomir Majewski

Przegl Dermatol 2016, 103, 162–168

DOI: https://doi.org/10.5114/dr.2016.59139

Online publish date: 2016/05/04

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Antimicrobial peptides (AMPs), known as “natural antibiotics”, are the first line of defense in humans as effector molecules of the innate immune system of the skin. They present activity against a broad spectrum of bacteria, fungi, parasites and enveloped viruses. An increasing number of studies report altered expression of AMPs in human cancers. Antimicrobial peptides such as human β defensins, human cathelicidin, ribonuclease 7 and psoriasin, a member of S100 proteins, are suggested to play a role in tumor progression and tumor suppression in pre-malignant skin lesions and malignancies. Noticeable changes in AMPs expression in skin tumorigenesis suggest a correlation between peptides and cutaneous cancers, though it is still a matter of discussion. In this article we review recent studies on the relationship between antimicrobial peptides and skin tumorigenesis.

keywords:

The role of antimicrobial peptides in skin tumorigenesis

Małgorzata Marcinkiewicz , Sławomir Majewski

antimicrobial peptides, skin tumorigenesis, melanoma, nonmelanoma skin cancer

Małgorzata Marcinkiewicz

,

Sławomir Majewski