The role of aromatase in breast cancer

Katarzyna Jarząbek; Sławomir Wołczyński

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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5/2003
vol. 2

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abstract:

The role of aromatase in breast cancer

Katarzyna Jarząbek

,

Sławomir Wołczyński

(Prz Menopauz 2003, 5: 12–16)

Online publish date: 2003/10/17

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The most of breast cancer in postmenopausal women is estrogen-dependent. The main question is which source of estrogen: estradiol circulating in the plasma or estradiol locally produced in extragonadal sites is a major factor stimulating the growth of the tumour. It seems that the local biosynthesis of estrogens in different tissues plays a crucial role in the development and growth of breast tumours and aromatase is a key enzyme regulating the local synthesis of estrogens. In our study we present recent concepts of the mechanisms activating aromatase and the role of aromatase in breast tissue and breast cancer.

keywords:

The role of aromatase in breast cancer

Katarzyna Jarząbek , Sławomir Wołczyński

breast cancer, aromatase

Katarzyna Jarząbek

,

Sławomir Wołczyński