The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential

Kelvin Piña Batista; Kenia Piña; Aida Ramos; Ivan Fernandez Vega; Antonio Saiz; Marco Vega

doi:10.5114/wo.2019.91543

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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4/2019
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abstract:

Review paper

The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential

Kelvin Piña Batista

¹

,

Kenia Álvarez Reyes De Piña

²

,

Aida Antuña Ramos

¹

,

Ivan Fernandez Vega

¹

,

Antonio Saiz

¹

,

Marco A. Álvarez Vega

¹

Department of Neurosurgery, Central University Hospital of Asturias, Oviedo, Spain
Hospital Vital Álvarez Buylla, Mieres, Spain

Contemp Oncol (Pozn) 2019; 23 (4): 187-194

DOI: https://doi.org/10.5114/wo.2019.91543

Online publish date: 2019/12/30

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AMA

Piña Batista K, Piña KÁ, Ramos AA, Vega I, Saiz A, Vega MA. The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential. Contemporary Oncology/Współczesna Onkologia. 2019;23(4):187-194. doi:10.5114/wo.2019.91543.

APA

Piña Batista, K., Piña, K. Á., Ramos, A. A., Vega, I., Saiz, A.,  & Vega, M. A. (2019). The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential. Contemporary Oncology/Współczesna Onkologia, 23(4), 187-194. https://doi.org/10.5114/wo.2019.91543

Chicago

Piña Batista, Kelvin, Kenia Á Piña, Aida A Ramos, Ivan Fernandez Vega, Antonio Saiz,  and Marco A Vega. 2019. "The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential". Contemporary Oncology/Współczesna Onkologia 23 (4): 187-194. doi:10.5114/wo.2019.91543.

Harvard

Piña Batista, K., Piña, K., Ramos, A., Vega, I., Saiz, A.,  and Vega, M. (2019). The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential. Contemporary Oncology/Współczesna Onkologia, 23(4), pp.187-194. https://doi.org/10.5114/wo.2019.91543

MLA

Piña Batista, Kelvin et al. "The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential." Contemporary Oncology/Współczesna Onkologia, vol. 23, no. 4, 2019, pp. 187-194. doi:10.5114/wo.2019.91543.

Vancouver

Piña Batista K, Piña K, Ramos A, Vega I, Saiz A, Vega M. The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential. Contemporary Oncology/Współczesna Onkologia. 2019;23(4):187-194. doi:10.5114/wo.2019.91543.

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Lung adenocarcinoma (LA) is the most common cause of cancer-related death worldwide. Despite the advances over last decade in new targeted therapies, cancer genetics, diagnostics, staging, and surgical techniques as well as new chemotherapy and radiotherapy protocols, the death rate from LA remains high. The tumour microenvironment is composed of several cytokines, one of which is transforming growth factor b1 (TGF-β1), which modulates and mediates the expression of epithelial-mesenchymal transition (EMT), correlated with invasive growth in LAs, and exhibits its pleiotropic effects through binding to transmembrane receptors TbR-1 (also termed activin receptor-like kinases – ALKs) and TbR-2. Accordingly, there is an urgent need to elucidate the molecular mechanisms associated with the tumoural spreading process and therapeutic resistance of this serious pathology. In this review, we briefly discuss the current role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases, and give an overview of our current mechanistic understanding of the TGF-β1-related pathways in brain metastases progression, TGF-β1 pathway inhibitors that could be used for clinical treatment, and examination of models used to study these processes. Finally, we summarise the current progress in the therapeutic approaches targeting TGF-β1.

keywords:

The role of contextual signal TGF-β1 inducer of epithelial mesenchymal transition in metastatic lung adenocarcinoma patients with brain metastases: an update on its pathological significance and therapeutic potential

Kelvin Piña Batista 1 , Kenia Álvarez Reyes De Piña 2 , Aida Antuña Ramos 1 , Ivan Fernandez Vega 1 , Antonio Saiz 1 , Marco A. Álvarez Vega 1

TGF-β1, EMT, lung adenocarcinoma, brain metastasis, pathology

Kelvin Piña Batista

¹

,

Kenia Álvarez Reyes De Piña

²

,

Aida Antuña Ramos

¹

,

Ivan Fernandez Vega

¹

,

Antonio Saiz

¹

,

Marco A. Álvarez Vega

¹