The role of genetic, autoimmune, infective and hormonal factors in pathogenesis
of lichen sclerosus – review of the literature

Agnieszka Cegielska; Beata Imko-Walczuk; Janusz Jaśkiewicz; Waldemar Placek

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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4/2011
vol. 98

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abstract:

Review paper

The role of genetic, autoimmune, infective and hormonal factors in pathogenesis of lichen sclerosus – review of the literature

Agnieszka Cegielska

,

Beata Imko-Walczuk

,

Janusz Jaśkiewicz

,

Waldemar Placek

Przegl Dermatol 2011, 98, 355–361

Online publish date: 2011/08/18

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Lichen sclerosus (LS) is a chronic inflammatory disease with a characteristic clinical appearance and specific histopathology. Clinically is characterized by plaques of ivory white atrophic lesions licalized, chiefly on genitals, and also in extragenital localisation. Both males and females at any age are affected. The aetiology of LS remains unclear. In the literature, the hypothesis of possible role of genetic, autoimmune, infectious and hormonal factors are found. Oxidative stress may also play additional role. Understanding of lichen sclerosus pathogenesis may improve its therapy and allow to avoid its complications.

keywords:

The role of genetic, autoimmune, infective and hormonal factors in pathogenesis of lichen sclerosus – review of the literature

Agnieszka Cegielska , Beata Imko-Walczuk , Janusz Jaśkiewicz , Waldemar Placek

lichen sclerosus at atrophicus, lichen sclerosus, etiopathogenesis, HLA, ECM1, hormons, oxidative stress

Agnieszka Cegielska

,

Beata Imko-Walczuk

,

Janusz Jaśkiewicz

,

Waldemar Placek