eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications
6/2022
vol. 39
 
Share:
Send email
Share:
abstract:
Original paper

The role of heterodimer IL 17A/F in atopic dermatitis

Joanna Krzysiek
1
,
Aleksandra Lesiak
1
,
Małgorzata Szybka
2
,
Anna Michalak
2
,
Dorota Pastuszak-Lewandoska
2
,
Janina Grzegorczyk
2
,
Magdalena Ciążyńska
3
,
Joanna Narbutt
1

  1. Department of Dermatology, Pediatric and Dermatological Oncology, Medical University of Lodz, Lodz, Poland
  2. Microbiology and Laboratory Medical Immunology, Medical University of Lodz, Lodz, Poland
  3. Department of Proliferative Diseases, Nicolaus Copernicus Multidisciplinary Centre for Oncology and Traumatology, Lodz, Poland
Adv Dermatol Allergol 2022; XXXIX (6): 1093-1100
DOI: https://doi.org/10.5114/ada.2022.122604
Online publish date: 2022/12/22
View full text Get citation
 
Introduction
The importance of multifactorial dysregulation in immune response is well recognised in atopic dermatitis (AD). Th17 family cytokine IL-17 (IL-17A-F) is of significance in both acute and chronic phase of AD.

Aim
We analysed the differences between serum levels of IL-17A/F and IL-17A, IL-17-F, IL-13, IL-4, association of rs2275913 IL-17A and rs763780 IL-17F gene polymorphisms in paediatric AD patients and control subjects.

Material and methods
We assessed 30 children with AD and 30 healthy patients aged 2–12 years. Eczema Area and Severity Index, Investigator Global Assessment and Scoring Atopic Dermatitis scales were used to analyse the severity of skin lesions in AD patients. Genotyping was performed using PCR and the serum concentrations of IL-17A/F, IL-17A, IL-17F, while IL-13 and IL-4 interleukins were determined by enzyme-linked immuno-sorbent assays (ELISA).

Results
The revised median assessment scoring in disease severity showed that the studied AD population had a moderate course of the disease. The obtained results indicated elevated plasma levels of IL-17A/F and IL-17-13 in AD patients with no statistically significance of IL-17A, IL-17F and IL-4 compared to controls. AD duration was positively correlated with IL-13 levels and negatively with IL-17A/F (p < 0.05). Moreover, there was no significant difference between case and control groups in the frequency of genotypes and alleles at rs2275913 IL-17A and rs763780 IL-17F polymorphisms (p > 0.05).

Conclusions
This study demonstrates increased levels of IL-17A/F in atopic patients, which is positively correlated with severity of the disease and the early phase of the disease. These results highlight a functional role of this cytokine in the pathogenesis of AD in paediatric patients.

keywords:

atopic dermatitis, IL-17, IL-17A/F, polymorphism, paediatric
FEATURED PRODUCTS
BOOKS
• Atopowe Zapalenie Skóry • Choroby alergiczne w praktyce lekarza rodzinnego • Alergologia – kompendium
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.