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2/2018
vol. 120 abstract:
Review paper
The role of integrins in eye diseases
Justyna Żaworonek
,
Beata Żelazowska-Rutkowska
,
Anna Bryl
,
Małgorzata Mrugacz
,
Bogdan Cylwik
Online publish date: 2018/10/25
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Integrins belong to the cell adhesion molecules. Integrins and their ligands play the main role in physiological and pathological processes: cell migration, cell differentiation, hemostasis, adhesion, angiogenesis and wound healing. The main task of integrin is to facilitate biochemical and mechanical signal transmission across the plasma membrane in a bidirectional manner. The signals trigger integrin transformation from an inactive form into a ligand-binding state. Integrins play an important role in physiological (embryogenesis, tissue growth and development) and pathological (allergy, inflammation, cancer) processes, being particularly involved in dry eye disease, age-related macular degeneration and diabetic macular edema. Improved understanding of integrins can contribute to the development of new diagnostic methods and advances in immunotherapy.
keywords:
integrins α and β, eye diseases, adhesion molecules, ligand |
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