The role of lipids in psoriasis

Anna Baran; Paulina Kiluk; Hanna Myśliwiec; Iwona Flisiak

doi:10.5114/dr.2017.71834

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2017
vol. 104

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abstract:

Review paper

The role of lipids in psoriasis

Anna Baran

,

Paulina Kiluk

,

Hanna Myśliwiec

,

Iwona Flisiak

Dermatol Rev/Przegl Dermatol 2017, 104, 619-635

DOI: https://doi.org/10.5114/dr.2017.71834

Online publish date: 2017/12/05

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Psoriasis, affecting 2–4% of the world’s population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.

keywords:

The role of lipids in psoriasis

Anna Baran , Paulina Kiluk , Hanna Myśliwiec , Iwona Flisiak

diet, obesity, lipids, psoriasis, metabolic syndrome

Anna Baran

,

Paulina Kiluk

,

Hanna Myśliwiec

,

Iwona Flisiak