The role of microRNAs in hepatocellular carcinoma: Therapeutic targeting of tumor suppressor and oncogenic genes

Nasim Rahimi Farsi; Bahman Naghipour; Parviz Shahabi; Reza Safaralizadeh; Khalil Hajiasgharzadeh; Narges Dastmalchi; Mohammad Reza Alipour

doi:10.5114/ceh.2023.131669

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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4/2023
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abstract:

Review paper

The role of microRNAs in hepatocellular carcinoma: Therapeutic targeting of tumor suppressor and oncogenic genes

Nasim Rahimi Farsi

^{1, 2}

,

Bahman Naghipour

³

,

Parviz Shahabi

⁴

,

Reza Safaralizadeh

⁵

,

Khalil Hajiasgharzadeh

¹

,

Narges Dastmalchi

²

,

Mohammad Reza Alipour

^{1, 4}

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Biology, University College of Nabi Akram, Tabriz, Iran
Department of Anesthesiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Clin Exp HEPATOL 2023; 9, 4: 307-319

DOI: https://doi.org/10.5114/ceh.2023.131669

Online publish date: 2023/09/28

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Hepatocellular carcinoma (HCC) is a severe malignant liver cancer with a poor prognosis and a high mortality rate. This carcinoma is a multistage process that begins with chronic hepatitis and progresses to cirrhosis, dysplastic nodules, and eventually HCC. However, the exact molecular etiology remains unclear. MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of numerous genes. These molecules have become significant participants in several functions, including cell proliferation, differentiation, development, and tumorrelated properties. They have a pivotal role in carcinogenesis as oncogenes or tumor suppressor genes. Furthermore, some investigations have shown that particular miRs might be used as predictive or diagnostic markers and therapeutic targets in HCC therapy. This review study summarizes the current level of knowledge on the role of miRs in the initiation and progression of HCC.

keywords:

The role of microRNAs in hepatocellular carcinoma: Therapeutic targeting of tumor suppressor and oncogenic genes

Nasim Rahimi Farsi 1, 2 , Bahman Naghipour 3 , Parviz Shahabi 4 , Reza Safaralizadeh 5 , Khalil Hajiasgharzadeh 1 , Narges Dastmalchi 2 , Mohammad Reza Alipour 1, 4

hepatocellular carcinoma (HCC), microRNA, therapeutic target, oncogene, tumor suppressor

Nasim Rahimi Farsi

^{1, 2}

,

Bahman Naghipour

³

,

Parviz Shahabi

⁴

,

Reza Safaralizadeh

⁵

,

Khalil Hajiasgharzadeh

¹

,

Narges Dastmalchi

²

,

Mohammad Reza Alipour

^{1, 4}