The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?

Malwina Grobelna; Ewa Strauss; Zbigniew Krasiński

doi:10.5114/kitp.2019.88602

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

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abstract:

Review paper

The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?

Malwina K. Grobelna

¹

,

Ewa Strauss

^{1, 2}

,

Zbigniew Krasiński

¹

Department of Vascular, Endovascular Surgery, Angiology and Phlebology Poznan University of Medical Sciences, Poznan, Poland
Institute of Human Genetics, Polish Academy of Sciences, Poznan Poland

Kardiochir Torakochir Pol 2019; 16 (3): 128-132

DOI: https://doi.org/10.5114/kitp.2019.88602

Online publish date: 2019/10/28

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AMA

Grobelna MK, Strauss E, Krasiński Z. The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2019;16(3):128-132. doi:10.5114/kitp.2019.88602.

APA

Grobelna, M. K., Strauss, E.,  & Krasiński, Z. (2019). The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 16(3), 128-132. https://doi.org/10.5114/kitp.2019.88602

Chicago

Grobelna, Malwina K, Ewa Strauss,  and Zbigniew Krasiński. 2019. "The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 16 (3): 128-132. doi:10.5114/kitp.2019.88602.

Harvard

Grobelna, M., Strauss, E.,  and Krasiński, Z. (2019). The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 16(3), pp.128-132. https://doi.org/10.5114/kitp.2019.88602

MLA

Grobelna, Malwina et al. "The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 16, no. 3, 2019, pp. 128-132. doi:10.5114/kitp.2019.88602.

Vancouver

Grobelna M, Strauss E, Krasiński Z. The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2019;16(3):128-132. doi:10.5114/kitp.2019.88602.

PlumX metrics:

Lately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated with lipid and glucose metabolism, chronic inflammation, atherosclerosis and hypertension. Serum level of PCSK9 is different in patients affected by certain illnesses (whose risk increases with age) than in healthy individuals. The same could be observed in the case of chronic inflammation. In this review we summarize what is known about the role PCSK9 in human metabolism and how this could affect the vascular aging process. Based on the available sources, we prove that PCSK9 is involved in many biochemical pathways associated with vascular aging. In the future, treatments using PCSK9 inhibition may not only reduce the cardiovascular risk but also slow down this process.

keywords:

The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?

Malwina K. Grobelna 1 , Ewa Strauss 1, 2 , Zbigniew Krasiński 1

vascular aging, PCSK9, atherosclerosis, inflammation, cholesterol

Malwina K. Grobelna

¹

,

Ewa Strauss

^{1, 2}

,

Zbigniew Krasiński

¹