The role of serum vitamin D levels in vitiligo

Ebru Karagün; Can Ergin; Sevim Baysak; Gönül Erden; Habibullah Aktaş; Özlem Ekiz

doi:10.5114/pdia.2016.59507

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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4/2016
vol. 33

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abstract:

Original paper

The role of serum vitamin D levels in vitiligo

Ebru Karagün

,

Can Ergin

,

Sevim Baysak

,

Gönül Erden

,

Habibullah Aktaş

,

Özlem Ekiz

Adv Dermatol Allergol 2016; XXXIII (4): 300–302

DOI: https://doi.org/10.5114/pdia.2016.59507

Online publish date: 2016/08/16

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Introduction: Vitiligo is a common acquired pigmentary skin disorder. Vitamin D is responsible for skin pigmentation, increases tyrosinase activity and melanogenesis, and exhibits immunoregulatory functions. Low levels of vitamin D are associated with many autoimmune diseases, including systemic lupus, diabetes mellitus, rheumatoid arthritis, multiple sclerosis and alopecia areata. Few reports have evaluated serum vitamin D levels in vitiligo patients, and their results are conflicting.

Aim: To evaluate serum vitamin D levels of vitiligo patients and compare the results with controls.

Material and methods: In total, 50 vitiligo patients and 47 controls were enrolled in the study. Vitamin D levels were measured from blood samples. Group comparisons were performed using appropriate statistical methods.

Results: The patients had lower serum vitamin D levels than the controls, but this difference was not significant (p = 0.570).

Conclusions: It remains unknown whether vitamin D deficiency causes vitiligo. Larger controlled studies are required to prove whether low circulating vitamin D is a causative factor in vitiligo.

keywords:

The role of serum vitamin D levels in vitiligo

Ebru Karagün , Can Ergin , Sevim Baysak , Gönül Erden , Habibullah Aktaş , Özlem Ekiz

vitiligo, vitamin D, autoimmune diseases, etiopathogenesis

Ebru Karagün

,

Can Ergin

,

Sevim Baysak

,

Gönül Erden

,

Habibullah Aktaş

,

Özlem Ekiz