The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Szpecht D, Gadzinowski J, Nowak I, et al. The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation. Central European Journal of Immunology. 2017;42(3):287-293. doi:10.5114/ceji.2017.67000.

APA

Szpecht, D., Gadzinowski, J., Nowak, I., Cygan, D., Seremak-Mrozikiewicz, A.,  & Kurzawińska, G. et al. (2017). The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation. Central European Journal of Immunology, 42(3), 287-293. https://doi.org/10.5114/ceji.2017.67000

Chicago

Szpecht, Dawid, Janusz Gadzinowski, Irmina Nowak, Dorothy Cygan, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska,  and Dariusz Madajczak et al. 2017. "The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation". Central European Journal of Immunology 42 (3): 287-293. doi:10.5114/ceji.2017.67000.

Harvard

Szpecht, D., Gadzinowski, J., Nowak, I., Cygan, D., Seremak-Mrozikiewicz, A., Kurzawińska, G., Madajczak, D., Drews, K.,  and Szymankiewicz, M. (2017). The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation. Central European Journal of Immunology, 42(3), pp.287-293. https://doi.org/10.5114/ceji.2017.67000

MLA

Szpecht, Dawid et al. "The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation." Central European Journal of Immunology, vol. 42, no. 3, 2017, pp. 287-293. doi:10.5114/ceji.2017.67000.

Vancouver

Szpecht D, Gadzinowski J, Nowak I, Cygan D, Seremak-Mrozikiewicz A, Kurzawińska G et al. The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation. Central European Journal of Immunology. 2017;42(3):287-293. doi:10.5114/ceji.2017.67000.

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Introduction: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects primarily preterm infants. Genetic factors are also taken into consideration in the pathogenesis of BPD. Genetic predispositions to higher production of inflammation mediators seem to be crucial.

Material and methods: The aim of this study was to evaluate the possible relationship between polymorphisms: interleukin-1β +3953 C>T, interleukin-6 -174 G>C and -596 G>A, tumour necrosis factor -308 G>A and interleukin-1RN VNTR 86bp and the occurrence of BPD in a population of 100 preterm infants born from singleton pregnancy, before 32+0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities.

Results: In the study population BPD was diagnosed in 36 (36%) newborns. Among the studied polymorphisms we found the higher prevalence for BPD developing of the following genotypes: 1/2 (OR 1.842 [0.673-5.025] and 2/2 IL-1RN (OR 1.75 [0.418-6.908] 86bpVNTR; GC (2.222 [0.658-8.706]) and CC IL-6 -174G>C (1.6 [0.315-8.314]) and GA (2.753 [0.828-10.64]) and AA (1.5 [0.275-8.067] IL-6 -596G>A), GA 1.509 (0.515-4.301) TNF-α -308G>A. However, these finding were not statistically significant.

Conclusions: Genetic factors are undeniably involved in the pathogenesis of BPD. In the times of individualised therapy finding genes responsible for BPD might allow the development of new treatment strategies. A new way of specific therapy could ensure the reduction of complications connected with BPD and treatment costs.

keywords:

The significance of IL-1β +3953C>T, IL-6 -174G>C and -596G>A, TNF-α -308G>A gene polymorphisms and 86 bp variable number tandem repeat polymorphism of IL-1RN in bronchopulmonary dysplasia in infants born before 32 weeks of gestation

Dawid Szpecht , Janusz Gadzinowski , Irmina Nowak , Dorothy Cygan , Agnieszka Seremak-Mrozikiewicz , Grażyna Kurzawińska , Dariusz Madajczak , Krzysztof Drews , Marta Szymankiewicz

gene, polymorphism, bronchopulmonary dysplasia, preterm newborn

Dawid Szpecht

,

Janusz Gadzinowski

,

Irmina Nowak

,

Dorothy Cygan

,

Agnieszka Seremak-Mrozikiewicz

,

Grażyna Kurzawińska

,

Dariusz Madajczak

,

Krzysztof Drews

,

Marta Szymankiewicz