The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland

Hanna Romanowicz; Beata Smolarz; Jakub Baszczyński; Marek Zadrożny; Andrzej Kulig; Bożena Góralczyk; Ireneusz Połać; Tomasz Pertyński

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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1/2011
vol. 10

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abstract:

Original paper

The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination (XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland

Hanna Romanowicz

,

Beata Smolarz

,

Jakub Baszczyński

,

Marek Zadrożny

,

Andrzej Kulig

,

Bożena Góralczyk

,

Ireneusz Połać

,

Tomasz Pertyński

Przegląd Menopauzalny 2011; 1: 10–14

Online publish date: 2011/03/16

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AMA

Romanowicz H, Smolarz B, Baszczyński J, et al. The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland. Menopause Review/Przegląd Menopauzalny. 2011;10(1):10-14.

APA

Romanowicz, H., Smolarz, B., Baszczyński, J., Zadrożny, M., Kulig, A.,  & Góralczyk, B. et al. (2011). The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland. Menopause Review/Przegląd Menopauzalny, 10(1), 10-14.

Chicago

Romanowicz, Hanna, Beata Smolarz, Jakub Baszczyński, Marek Zadrożny, Andrzej Kulig, Bożena Góralczyk,  and Ireneusz Połać et al. 2011. "The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland". Menopause Review/Przegląd Menopauzalny 10 (1): 10-14.

Harvard

Romanowicz, H., Smolarz, B., Baszczyński, J., Zadrożny, M., Kulig, A., Góralczyk, B., Połać, I.,  and Pertyński, T. (2011). The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland. Menopause Review/Przegląd Menopauzalny, 10(1), pp.10-14.

MLA

Romanowicz, Hanna et al. "The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland." Menopause Review/Przegląd Menopauzalny, vol. 10, no. 1, 2011, pp. 10-14.

Vancouver

Romanowicz H, Smolarz B, Baszczyński J, Zadrożny M, Kulig A, Góralczyk B et al. The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination 
(XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland. Menopause Review/Przegląd Menopauzalny. 2011;10(1):10-14.

Background : Single nucleotide polymorphisms in the DNA repair genes have been extensively studied in association with various human cancers such as breast cancer.

Material and methods : We investigated an association of polymorphisms in the DNA repair genes

XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls.

Results : The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04).

Conclusion : G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women.

keywords:

The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination (XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland

Hanna Romanowicz , Beata Smolarz , Jakub Baszczyński , Marek Zadrożny , Andrzej Kulig , Bożena Góralczyk , Ireneusz Połać , Tomasz Pertyński

XRCC2, RAD51, breast cancer, gene polymorphism

Hanna Romanowicz

,

Beata Smolarz

,

Jakub Baszczyński

,

Marek Zadrożny

,

Andrzej Kulig

,

Bożena Góralczyk

,

Ireneusz Połać

,

Tomasz Pertyński