The structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part two

Jagoda Pelc; Magdalena Czarnecka-Operacz; Zygmunt Adamski

doi:10.5114/ada.2018.75234

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

The structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part two

Jagoda Pelc

,

Magdalena Czarnecka-Operacz

,

Zygmunt Adamski

Adv Dermatol Allergol 2018; XXXV (2): 123-127

DOI: https://doi.org/10.5114/ada.2018.75234

Online publish date: 2018/04/24

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Atopic dermatitis (AD) is a chronic and recurrent disease induced by underlying defects of the epidermal barrier and immunological disorders, typical of atopic diseases. The genetic and immunological mechanisms (outlined in the previous paper) affecting the dysfunction of the barrier are intensified by environmental factors, e.g. airborne and food allergens, infections and stress. For this reason, proper skin care, which prevents further damage and restores the epidermal barrier is of such importance in the field of AD therapy. Appropriate therapy is based on emollients which, coupled with anti-inflammatory and antipruritic treatment, should be used as the first-line therapy. The aim of the present paper is to outline the effects of the abovementioned factors on the dysfunction of the epidermal barrier as well as to emphasize the importance of proper atopic skin care in maintaining the integrity of the barrier and preventing exacerbation of the disease.

keywords:

The structure and function of the epidermal barrier in patients with atopic dermatitis – treatment options. Part two

Jagoda Pelc , Magdalena Czarnecka-Operacz , Zygmunt Adamski

atopic dermatitis, epidermal barrier, therapy, emollients

Jagoda Pelc

,

Magdalena Czarnecka-Operacz

,

Zygmunt Adamski