The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls

Samah Shalal Sultan Al-Rakabi; Milad Parvinzad Leilan; Gholamreza Tavoosidana; Houshang Nemati; Masoud Sadeghi

doi:10.5114/dr.2024.142746

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2024
vol. 111

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abstract:

Original article

The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls

Samah Shalal Sultan Al-Rakabi

¹

,

Milad Parvinzad Leilan

²

,

Gholamreza Tavoosidana

²

,

Houshang Nemati

³

,

Masoud Sadeghi

³

Department of Biology Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Dermatol Rev/Przegl Dermatol 2024, 111, 113-119

DOI: https://doi.org/10.5114/dr.2024.142746

Online publish date: 2024/09/13

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AMA

Sultan Al-Rakabi S, Leilan M, Tavoosidana G, Nemati H, Sadeghi M. The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls. Dermatology Review/Przegląd Dermatologiczny. 2024;111(2):113-119. doi:10.5114/dr.2024.142746.

APA

Sultan Al-Rakabi, S., Leilan, M., Tavoosidana, G., Nemati, H.,  & Sadeghi, M. (2024). The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls. Dermatology Review/Przegląd Dermatologiczny, 111(2), 113-119. https://doi.org/10.5114/dr.2024.142746

Chicago

Sultan Al-Rakabi, Samah Shalal, Milad Parvinzad Leilan, Gholamreza Tavoosidana, Houshang Nemati,  and Masoud Sadeghi. 2024. "The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls". Dermatology Review/Przegląd Dermatologiczny 111 (2): 113-119. doi:10.5114/dr.2024.142746.

Harvard

Sultan Al-Rakabi, S., Leilan, M., Tavoosidana, G., Nemati, H.,  and Sadeghi, M. (2024). The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls. Dermatology Review/Przegląd Dermatologiczny, 111(2), pp.113-119. https://doi.org/10.5114/dr.2024.142746

MLA

Sultan Al-Rakabi, Samah Shalal et al. "The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls." Dermatology Review/Przegląd Dermatologiczny, vol. 111, no. 2, 2024, pp. 113-119. doi:10.5114/dr.2024.142746.

Vancouver

Sultan Al-Rakabi S, Leilan M, Tavoosidana G, Nemati H, Sadeghi M. The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls. Dermatology Review/Przegląd Dermatologiczny. 2024;111(2):113-119. doi:10.5114/dr.2024.142746.

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Introduction:
Nitric oxide (NO) and resistin play significant roles in the inflammatory processes and pathogenesis of psoriasis, and are associated with comorbidities often seen in psoriasis patients.

Objective:
We evaluated the correlation between the level of resistin gene expression in peripheral blood mononuclear cells (PBMCs) and the serum NO levels in patients with psoriasis.

Material and methods:
We studied 60 cases with psoriasis and 40 healthy controls. The serum level of NO in the blood of the study groups, psoriasis and healthy control respectively, was determined using the Griess technique and the Kiazist kit (Kiazist, Iran). In addition, we performed real-time PCR to assay resistin gene expression in PBMCs from both groups.

Results:
The serum NO levels in patients with psoriasis were significantly higher than in healthy controls (p = 0.001). The resistin gene expression in PBMCs was significantly elevated in psoriatic patients group (p = 0.001).

Conclusions:
The findings revealed that, in addition to having higher levels of platelets and WBC in their serum, patients with psoriasis, have higher levels of NO and upregulated resistin gene expression, which is likely due to the pathological role of these factors in the occurrence or maintenance of psoriasis. The rise in NO levels and resistin gene expression suggests they may play a role in the pathology of psoriasis.

keywords:

The study and comparison of blood serum nitric oxide levels and resistin gene expression in psoriasis patients and healthy controls

Samah Shalal Sultan Al-Rakabi 1 , Milad Parvinzad Leilan 2 , Gholamreza Tavoosidana 2 , Houshang Nemati 3 , Masoud Sadeghi 3

psoriasis, nitric oxide, resistin, blood, gene expression

Samah Shalal Sultan Al-Rakabi

¹

,

Milad Parvinzad Leilan

²

,

Gholamreza Tavoosidana

²

,

Houshang Nemati

³

,

Masoud Sadeghi

³