eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2019
vol. 44
 
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abstract:
Review paper

Therapeutic potential of curcumin in eye diseases

Dorota M. Radomska-Leśniewska
1
,
Anna Osiecka-Iwan
1
,
Anna Hyc
1
,
Agata Góźdź
1
,
Anna M. Dąbrowska
2
,
Piotr Skopiński
1

  1. Department of Histology and Embryology, Medical University of Warsaw, Poland
  2. Department of Ophthalmology, Second Faculty of Medicine, Medical University of Warsaw, Poland
(Centr Eur J Immunol 2019; 44 (2): 181-189)
DOI: https://doi.org/10.5114/ceji.2019.87070
Online publish date: 2019/07/30
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Curcumin (diferuloylmethane) derived from the rhizome of Curcuma longa L. has been used for thousands of years in traditional Chinese medicine and Ayurvedic medicine in Asian countries to treat liver diseases, rheumatoid diseases, diabetes, atherosclerosis, infectious diseases and cancer. It exhibits a wide range of pharmacological properties, which include antioxidant, anti-inflammatory, antimutagenic, antimicrobial and anticancer activity. Herein the mechanisms of curcumin impact on oxidative stress, angiogenesis and inflammatory processes are described indicating that curcumin use may inhibit those pathological conditions and restore body homeostasis. Its effectiveness was also proved for major eye diseases. In this review, the influence of curcumin on eye diseases, such as glaucoma, cataract, age-related macular degeneration, diabetic retinopathy, corneal neovascularization, corneal wound healing, dry eye disease, conjunctivitis, pterygium, anterior uveitis are reported. The analysis of a number of clinical and preclinical investigations indicates that curcumin may be used as a therapeutic agent in the treatment of various eye disorders.
keywords:

curcumin, angiogenesis, glaucoma, diabetic retinopathy, conjunctivitis, cataract, eye disease, reactive oxygen species (ROS), age-related macular degeneration (AMD)
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